Kagitani-Shimono Kuriko, Kato Yoko, Hanaie Ryuzo, Matsuzaki Junko, Tanigawa Junpei, Iwatani Yoshiko, Azuma Junji, Taniike Masako
Division of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Epilepsy center, Osaka University Hospital, Suita, Osaka, Japan.
Division of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan.
Epilepsy Behav. 2018 Oct;87:159-166. doi: 10.1016/j.yebeh.2018.05.035. Epub 2018 Aug 16.
Benign childhood epilepsy with centrotemporal spikes (BECTS), also known as rolandic epilepsy, has recently been reported to be associated with variable degrees of cognitive dysfunction. Many studies reported poor language ability in children with BECTS compared with healthy control children. To elucidate the harmful effects of BECTS on language cognition, we studied the magnetoencephalographic activity elicited by an auditory language comprehension task.
The participants (N = 20) included 10 children diagnosed with BECTS (aged 10.8 ± 2.8 years) and 10 age-matched healthy children (control) (aged 10.6 ± 1.6 years). Cognitive function was assessed using general intellectual function and language ability. In patients with BECTS, we reviewed the clinical course and electroencephalogram (EEG) findings. We recorded the cortical responses elicited by an auditory language comprehension task using magnetoencephalography (MEG). We compared those results between groups and analyzed the correlation with cognitive scores and frequency of spikes.
The full-scale intelligence quotient (FSIQ) by the Wechsler Intelligence Scale for Children-4th edition was significantly reduced in the group with BECTS (96.4 ± 12.3) compared with the control group (110.0 ± 7.4). In half of the group with BECTS, the auditory comprehension score fell below the age-standard level. In the group with BECTS, the cortical activation during the task showed reduced intensity in language-associated areas such as the bilateral primary auditory cortex, left superior and mid-temporal areas, and inferior frontal area compared with those in the control group. In addition, the cortical activation in the left superior temporal area was negatively correlated with spike frequency and positively correlated with FSIQ in the group with BECTS. Conversely, the right inferior frontal and mid-temporal areas had increased the activations in the group with BECTS. From the time frequency analysis, low gamma band event-related desynchronization was reduced in the group with BECTS.
Epileptic spikes negatively influenced responsiveness to the auditory language comprehension task in the language-associated cortices. These findings suggest that epileptic spikes could have a negative impact on the functional activity in rolandic areas and become a reason to change the functional development of the language network.
儿童中央颞区棘波良性癫痫（BECTS），也称为罗兰多癫痫，最近有报道称其与不同程度的认知功能障碍有关。许多研究报告称，与健康对照儿童相比，BECTS患儿的语言能力较差。为了阐明BECTS对语言认知的有害影响，我们研究了听觉语言理解任务引发的脑磁图活动。
参与者（N = 20）包括10名被诊断为BECTS的儿童（年龄10.8±2.8岁）和10名年龄匹配的健康儿童（对照组）（年龄10.6±1.6岁）。使用一般智力功能和语言能力评估认知功能。对于BECTS患者，我们回顾了临床病程和脑电图（EEG）结果。我们使用脑磁图（MEG）记录了听觉语言理解任务引发的皮层反应。我们比较了两组之间的结果，并分析了其与认知分数和棘波频率的相关性。
与对照组（110.0±7.4）相比，BECTS组使用韦氏儿童智力量表第四版测得的全量表智商（FSIQ）显著降低（96.4±12.3）。在BECTS组的一半儿童中，听觉理解分数低于年龄标准水平。与对照组相比，BECTS组在任务期间的皮层激活在与语言相关的区域，如双侧初级听觉皮层、左侧颞上和颞中区域以及额下区域，强度降低。此外，在BECTS组中，左侧颞上区域的皮层激活与棘波频率呈负相关，与FSIQ呈正相关。相反，在BECTS组中，右侧额下和颞中区域的激活增加。从时频分析来看，BECTS组的低伽马波段事件相关去同步化减少。
癫痫棘波对语言相关皮层中听觉语言理解任务的反应性产生负面影响。这些发现表明，癫痫棘波可能会对罗兰多区域的功能活动产生负面影响，并成为改变语言网络功能发育的一个原因。
