Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Institute of Research in Public Health of the University of Montreal (IRSPUM), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, Quebec, H3C 3J7, Canada.
Laboratory of Toxicology-Microbiology and Environmental Health (LR17ES70), Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia.
Toxicol Lett. 2018 Oct 15;296:132-138. doi: 10.1016/j.toxlet.2018.08.008. Epub 2018 Aug 16.
A controlled kinetic study was conducted in volunteers dermally exposed to the widely used lambda-cyhalothrin pyrethroid pesticide to document the time courses of relevant biomarkers of exposure, in order to better assess biomonitoring data in workers. Matador EC120 formulation (120 g/l) was applied on 40 cm of the forearm at a 0.25 mg/kg dose of lambda-cyhalothrin and left without occlusion or washing for 6 h. The application site was then washed thoroughly with soap and water. The kinetic time courses of cis-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid (CFMP) and 3-phenoxybenzoic acid (3-PBA) metabolites were determined in plasma and urine up to 84 h post-application. Results show that the fraction of lambda-cyhalothrin absorbed in the body was rapidly cleared following dermal contact. According to CFMP and 3-PBA plasma profiles, calculated mean apparent absorption half-lives (t) were 3 and 7.3 h, respectively, and corresponding mean apparent elimination t were 11.2 and 7.6 h. These differences suggest some metabolism at the site-of-entry and storage of metabolites by the dermal route. Toxicokinetic parameters calculated from urinary profiles confirm the values of absorption and elimination rates. Metabolites were almost completely excreted over the 84-h period post-application and, on average, 0.12 and 0.08% of the applied lambda-cyhalothrin dose was recovered in the urine as CFMP and 3-PBA, respectively, indicating a low dermal absorption fraction of this pyrethroid. This study showed the potential use of CFMP and 3-PBA biomarkers for the assessment of dermal exposure to lambda-cyhalothrin pyrethroid.
在志愿者中进行了一项对照的动力学研究，他们经皮暴露于广泛使用的 lambda-氯氟氰菊酯拟除虫菊酯农药，以记录相关暴露生物标志物的时间过程，以便更好地评估工人的生物监测数据。Matador EC120 制剂（120 g/l）以 lambda-氯氟氰菊酯 0.25 mg/kg 的剂量涂在前臂 40 cm 处，不进行封闭或清洗 6 小时。然后用肥皂和水彻底清洗应用部位。在应用后 84 小时内，在血浆和尿液中测定顺式-3-（2-氯-3,3,3-三氟丙烯-1-基）-2,2-二甲基环丙烷羧酸（CFMP）和 3-苯氧基苯甲酸（3-PBA）代谢物的动力学时间过程。结果表明，接触皮肤后，lambda-氯氟氰菊酯在体内吸收的部分迅速清除。根据 CFMP 和 3-PBA 血浆谱，计算得出的平均表观吸收半衰期（t）分别为 3 和 7.3 h，相应的平均表观消除半衰期（t）分别为 11.2 和 7.6 h。这些差异表明一些代谢物在皮肤进入部位和储存部位发生了代谢。从尿液谱计算得出的毒代动力学参数证实了吸收和消除率的值。代谢物在应用后 84 小时内几乎完全排泄，平均 0.12%和 0.08%的应用 lambda-氯氟氰菊酯剂量分别以 CFMP 和 3-PBA 的形式从尿液中回收，表明这种拟除虫菊酯的皮肤吸收率较低。本研究表明，CFMP 和 3-PBA 生物标志物可用于评估 lambda-氯氟氰菊酯拟除虫菊酯的经皮暴露。
