• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Annexin A1 in inflammation and breast cancer: a new axis in the tumor microenvironment.膜联蛋白A1在炎症和乳腺癌中的作用：肿瘤微环境中的新轴
Cell Adh Migr. 2018;12(5):417-423. doi: 10.1080/19336918.2018.1486143. Epub 2018 Aug 19.
2
Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment.膜联蛋白 A1 通过促进肿瘤微环境中替代型巨噬细胞的极化来增强乳腺癌的生长和迁移。
Sci Rep. 2017 Dec 20;7(1):17925. doi: 10.1038/s41598-017-17622-5.
3
Inflammation and cancer: role of annexin A1 and FPR2/ALX in proliferation and metastasis in human laryngeal squamous cell carcinoma.炎症与癌症：膜联蛋白A1和FPR2/ALX在人喉鳞状细胞癌增殖和转移中的作用
PLoS One. 2014 Dec 9;9(12):e111317. doi: 10.1371/journal.pone.0111317. eCollection 2014.
4
Annexin A1 as a Regulator of Immune Response in Cancer.膜联蛋白 A1 在癌症免疫反应中的调节作用。
Cells. 2021 Aug 30;10(9):2245. doi: 10.3390/cells10092245.
5
Triple-Negative Breast Cancer with High Levels of Annexin A1 Expression Is Associated with Mast Cell Infiltration, Inflammation, and Angiogenesis.高表达膜联蛋白 A1 的三阴性乳腺癌与肥大细胞浸润、炎症和血管生成有关。
Int J Mol Sci. 2019 Aug 27;20(17):4197. doi: 10.3390/ijms20174197.
6
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.膜联蛋白-1 与 NEMO 和 RIP1 相互作用，持续激活 IKK 复合物和 NF-κB：在乳腺癌转移中的作用。
Oncogene. 2011 Jul 14;30(28):3174-85. doi: 10.1038/onc.2011.28. Epub 2011 Mar 7.
7
Annexin A1 affects tumor metastasis through epithelial-mesenchymal transition: a narrative review.膜联蛋白A1通过上皮-间质转化影响肿瘤转移：一篇叙述性综述
Transl Cancer Res. 2022 Dec;11(12):4416-4433. doi: 10.21037/tcr-22-1544.
8
Annexin A1 expression and its prognostic significance in human breast cancer.膜联蛋白 A1 在人乳腺癌中的表达及其预后意义。
Neoplasma. 2010;57(3):253-9. doi: 10.4149/neo_2010_03_253.
9
Control of expression and activity of peroxisome proliferated-activated receptor γ by Annexin A1 on microglia during efferocytosis.在吞噬作用过程中，膜联蛋白 A1 对小胶质细胞中过氧化物酶体增殖物激活受体 γ 的表达和活性的控制。
Cell Biochem Funct. 2019 Oct;37(7):560-568. doi: 10.1002/cbf.3433. Epub 2019 Sep 3.
10
Phosphoproteomics reveals network rewiring to a pro-adhesion state in annexin-1-deficient mammary epithelial cells.磷酸化蛋白质组学揭示了膜联蛋白-1 缺陷型乳腺上皮细胞向促黏附状态的网络重排。
Breast Cancer Res. 2017 Dec 12;19(1):132. doi: 10.1186/s13058-017-0924-4.

引用本文的文献

1
Roles of Annexin A1 Expression in Small Cell Lung Cancer.膜联蛋白A1表达在小细胞肺癌中的作用。
Cancers (Basel). 2025 Apr 23;17(9):1407. doi: 10.3390/cancers17091407.
2
A Broad-Spectrum Chemokine Inhibitor Drives M2 Macrophage Polarization Through Modulation of the Myometrial Secretome.一种广谱趋化因子抑制剂通过调节子宫肌层分泌组驱动M2巨噬细胞极化。
Cells. 2025 Mar 30;14(7):514. doi: 10.3390/cells14070514.
3
Comprehensive analysis and experiments identified ANXA1 as an unfavorable prognosticator in glioma.综合分析和实验确定膜联蛋白A1（ANXA1）是神经胶质瘤预后不良的指标。
Transl Oncol. 2025 Mar;53:102286. doi: 10.1016/j.tranon.2025.102286. Epub 2025 Jan 21.
4
A new Neu-a syngeneic model of spontaneously metastatic HER2-positive breast cancer.一种新型 Neu-a 同源性自发性转移性 HER2 阳性乳腺癌模型。
Clin Exp Metastasis. 2024 Oct;41(5):733-746. doi: 10.1007/s10585-024-10289-z. Epub 2024 May 8.
5
An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review). annexin A1 在肿瘤微环境中的调控作用及其临床应用展望（综述）。
Int J Oncol. 2024 May;64(5). doi: 10.3892/ijo.2024.5639. Epub 2024 Mar 22.
6
Molecular subtyping and characterization of clear cell renal cell carcinoma by tumor differentiation trajectories.通过肿瘤分化轨迹对透明细胞肾细胞癌进行分子亚型分类及特征分析。
iScience. 2023 Oct 30;26(12):108370. doi: 10.1016/j.isci.2023.108370. eCollection 2023 Dec 15.
7
Automated exploitation of deep learning for cancer patient stratification across multiple types.基于深度学习的癌症患者多类型分层自动化挖掘
Bioinformatics. 2023 Nov 1;39(11). doi: 10.1093/bioinformatics/btad654.
8
Unsaturated Long-Chain Fatty Acids Activate Resident Macrophages and Stem Cells in a Human Skeletal Muscle Tissue Model.不饱和长链脂肪酸在人体骨骼肌组织模型中激活驻留巨噬细胞和干细胞。
Biology (Basel). 2023 Aug 9;12(8):1111. doi: 10.3390/biology12081111.
9
Suppression of VEGF and inflammatory cytokines, modulation of Annexin A1 and organ functions by galloylquinic acids in breast cancer model.没食子酰基奎宁酸通过抑制 VEGF 和炎症细胞因子、调节膜联蛋白 A1 对乳腺癌模型中器官功能的影响。
Sci Rep. 2023 Jul 28;13(1):12268. doi: 10.1038/s41598-023-37654-4.
10
NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer.NNAT 是氧化应激的一种新型介质，可抑制 ER+乳腺癌。
Mol Med. 2023 Jul 3;29(1):87. doi: 10.1186/s10020-023-00673-y.

本文引用的文献

1
Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment.膜联蛋白 A1 通过促进肿瘤微环境中替代型巨噬细胞的极化来增强乳腺癌的生长和迁移。
Sci Rep. 2017 Dec 20;7(1):17925. doi: 10.1038/s41598-017-17622-5.
2
Formyl peptide receptor 2 is regulated by RNA mimics and viruses through an IFN-β-STAT3-dependent pathway.通过 IFN-β-STAT3 依赖途径，甲酰肽受体 2 受到 RNA 模拟物和病毒的调控。
FASEB J. 2018 Mar;32(3):1468-1478. doi: 10.1096/fj.201700584RR. Epub 2018 Jan 3.
3
ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation.膜联蛋白A1通过核因子-κB和c-Myc在负反馈回路中抑制微小RNA-196a，以减少乳腺癌增殖。
Oncotarget. 2016 May 10;7(19):27007-20. doi: 10.18632/oncotarget.8875.
4
Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis.一组乳腺癌样本中膜联蛋白A1的表达：与肿瘤亚型及预后的关联
BMC Med. 2015 Jul 2;13:156. doi: 10.1186/s12916-015-0392-6.
5
Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling.膜联蛋白A1通过激活mTOR-S6信号通路，优先预测基底样乳腺癌患者的不良预后。
PLoS One. 2015 May 22;10(5):e0127678. doi: 10.1371/journal.pone.0127678. eCollection 2015.
6
Annexin-A1 controls an ERK-RhoA-NFκB activation loop in breast cancer cells.膜联蛋白A1调控乳腺癌细胞中的ERK-RhoA-NFκB激活环。
Biochem Biophys Res Commun. 2015 May 22;461(1):47-53. doi: 10.1016/j.bbrc.2015.03.166. Epub 2015 Apr 9.
7
Neoadjuvant therapy of early stage human epidermal growth factor receptor 2 positive breast cancer: latest evidence and clinical implications.早期人表皮生长因子受体 2 阳性乳腺癌的新辅助治疗：最新证据及临床意义。
Ther Adv Med Oncol. 2014 Sep;6(5):210-21. doi: 10.1177/1758834014535650.
8
Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice.内源性膜联蛋白 A1 是小鼠非酒精性脂肪性肝炎的新型保护决定因素。
Hepatology. 2014 Aug;60(2):531-44. doi: 10.1002/hep.27141. Epub 2014 May 12.
9
Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses.配体特异性构象变化的 G 蛋白偶联受体 ALX/FPR2 决定了促解决的功能反应。
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18232-7. doi: 10.1073/pnas.1308253110. Epub 2013 Oct 9.
10
Annexin-A1 regulates TLR-mediated IFN-β production through an interaction with TANK-binding kinase 1.膜联蛋白 A1 通过与 TANK 结合激酶 1 的相互作用调节 TLR 介导的 IFN-β 产生。
J Immunol. 2013 Oct 15;191(8):4375-82. doi: 10.4049/jimmunol.1301504. Epub 2013 Sep 18.

膜联蛋白A1在炎症和乳腺癌中的作用：肿瘤微环境中的新轴

Annexin A1 in inflammation and breast cancer: a new axis in the tumor microenvironment.

作者信息

Moraes Leonardo A, Ampomah Patrick B, Lim Lina H K

机构信息

a Department of Physiology , Yong Loo Lin School of Medicine, National University of Singapore, & NUS Immunology Program, Life Sciences Institute, Centre for Life Sciences, National University of Singapore , Singapore.

出版信息

Cell Adh Migr. 2018;12(5):417-423. doi: 10.1080/19336918.2018.1486143. Epub 2018 Aug 19.

DOI:10.1080/19336918.2018.1486143
PMID:30122097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6363057/
Abstract

Targeting inflammation in cancer has shown promise to improve and complement current therapies. The tumor microenvironment plays an important role in cancer growth and metastasis and -tumor associated macrophages possess pro-tumoral and pro-metastatic properties. Annexin A1 (ANXA1) is an immune-modulating protein with diverse functions in the immune system and in cancer. In breast cancer, high ANXA1 expression leads to poor prognosis and increased metastasis. Here, we will review ANXA1 as a modulator of inflammation, and discuss its importance in breast cancer and highlight its new role in alternative macrophage activation in the tumor microenvironment. This review may provide an updated understanding into the various roles of ANXA1 which may enable future therapeutic developments for the treatment of breast cancer.

摘要

针对癌症中的炎症进行治疗已显示出有望改善和补充当前疗法。肿瘤微环境在癌症的生长和转移中起着重要作用，肿瘤相关巨噬细胞具有促肿瘤和促转移特性。膜联蛋白A1（ANXA1）是一种免疫调节蛋白，在免疫系统和癌症中具有多种功能。在乳腺癌中，高ANXA1表达会导致预后不良和转移增加。在此，我们将综述ANXA1作为炎症调节剂的作用，并讨论其在乳腺癌中的重要性，突出其在肿瘤微环境中替代巨噬细胞活化方面的新作用。本综述可能会提供对ANXA1各种作用的最新认识，这可能有助于未来乳腺癌治疗的新疗法开发。