监测延迟到药房续药以评估抗逆转录病毒治疗的依从性。
Monitoring of Delay to Pharmacy Refill in Assessing Adherence to Antiretroviral Therapy.
机构信息
Program of Post-Graduation in Medicine and Health, Federal University of Bahia, Salvador, Brazil.
Program of Post-Graduation in Public Health, Federal University of Bahia, Vitória da Conquista, Brazil.
出版信息
J Pharm Pract. 2020 Apr;33(2):158-163. doi: 10.1177/0897190018795339. Epub 2018 Aug 20.
BACKGROUND
Adherence to antiretroviral (ARV) therapy remains a major challenge in HIV therapeutics.
OBJECTIVE
To assess the adherence to ARV therapy by measuring the delay in monthly refilling of ARV drugs using pharmacy records and to correlate this with HIV plasma RNA measurements and CD4 cell count.
METHOD
Records of 170 HIV-positive patients were examined to identify HIV viral load (VL)/CD4 results and the time interval to refill ARVs at the pharmacy. The correlation between the number of days missed to refill ARVs and plasma HIV-RNA detectability/CD4 count was performed using the Spearman's correlation coefficient ().
RESULTS
Fewer days missed to refill ARV was positively correlated with undetectable VL and increase in CD4 count ( = 0.407 and 0.237, respectively). Increase in adherence was correlated with longer retention in the cohort ( = 0.208).
CONCLUSION
Monitoring the delay to pick up ARVs from the pharmacy can be an important and simple tool to identify patients requiring assessment of their adherence.
背景
抗逆转录病毒 (ARV) 治疗的依从性仍然是 HIV 治疗中的一个主要挑战。
目的
通过测量每月 ARV 药物的延迟补充来评估对 ARV 治疗的依从性，并用此来关联 HIV 血浆 RNA 测量和 CD4 细胞计数。
方法
检查了 170 名 HIV 阳性患者的记录，以确定 HIV 病毒载量 (VL)/CD4 结果以及在药房补充 ARV 的时间间隔。使用 Spearman 相关系数 () 来分析错过补充 ARV 的天数与血浆 HIV-RNA 可检测性/CD4 计数之间的相关性。
结果
错过补充 ARV 的天数越少，与不可检测的 VL 和 CD4 计数的增加呈正相关（分别为 = 0.407 和 0.237）。依从性的增加与队列中保留时间的延长相关（ = 0.208）。
结论
从药房取 ARV 药物的延迟监测可以是识别需要评估其依从性的患者的一个重要且简单的工具。
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