Genomic Research Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Australia.
School of Applied Psychology and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
Neurobiol Learn Mem. 2018 Nov;155:330-336. doi: 10.1016/j.nlm.2018.08.001. Epub 2018 Aug 17.
The common polymorphism rs17518584, near the cell adhesion molecule 2 gene (CADM2), was previously identified as playing a role in information processing speed in a genome-wide association study of executive functions and processing speed performed in a cohort of non-demented older adults. In this study, we investigated this polymorphism in a younger population cohort (≤30 years old, median age 19 years), with no known memory or psychiatric disorders, for which we had phenotyped all participants for memory function (n = 514), and a subset of the participants for executive functions (n = 338), using a battery of tests measuring visuo-spatial memory, working memory, verbal memory, and frontal lobe functions (visual scanning, graphomotor speed, and cognitive flexibility). The polymorphism rs17518584 was genotyped by a restriction fragment length polymorphism assay and analysis indicated that the CADM2 polymorphism showed evidence of association with information processing speed as inferred from scores from the Stroop Word, Colour, and Colour-Word Tests (p = 0.005, p = 0.04, and p = 0.028, respectively, in a dominant inheritance model), as well as Trail Making Test Part A (p = 0.005 in an additive model). Significant associations of rs17518584 with scores from other tests of memory subtypes were not detected. The findings of this study provide further support for a role of CADM2 in aspects of cognitive function, in particular reading and information processing speed, and suggest that this role extends to younger individuals.
先前的全基因组关联研究发现，细胞黏附分子 2 基因（CADM2）附近的常见多态性 rs17518584 与执行功能和处理速度的信息处理速度有关。在这项研究中，我们在年龄较小的人群队列（≤30 岁，中位年龄 19 岁）中研究了这种多态性，这些人群没有已知的记忆或精神疾病病史，我们对所有参与者的记忆功能（n=514）和一部分参与者的执行功能（n=338）进行了表型分析，使用了一系列测试来测量视空间记忆、工作记忆、言语记忆和额叶功能（视觉扫描、图形运动速度和认知灵活性）。通过限制性片段长度多态性分析测定了 rs17518584 多态性，分析表明 CADM2 多态性与信息处理速度有关，这可以从 Stroop 字、颜色和颜色字测试的分数推断出来（在显性遗传模型中，p=0.005、p=0.04 和 p=0.028），以及 Trail Making Test 部分 A（在加性模型中，p=0.005）。未检测到 rs17518584 与其他记忆亚型测试分数的显著相关性。这项研究的结果进一步支持 CADM2 在认知功能方面的作用，特别是阅读和信息处理速度，并且表明这种作用延伸到了年轻人。
