Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima, 770-8514, Japan.
Forestry and Forest Products Research Institute (FFPRI), 1 Matsunosato, Tsukuba, Ibaraki, 305-8687, Japan.
J Antibiot (Tokyo). 2018 Nov;71(12):992-999. doi: 10.1038/s41429-018-0093-4. Epub 2018 Aug 20.
Four red polyketide pigments, uroleuconaphins A (1) and B (2) and their glucosides 3 and 4, were isolated from the red goldenrod aphid Uroleucon nigrotuberculatum. Although these red pigments exist only as glucosides 3 and 4 in the intact insect body, 3 and 4 convert instantly to aglycones 1 and 2 at death. Pigments 1 and 2 inhibited the growth of Lecanicillium sp. (Ascomycota: Cordycipitaceae) and 1, 2, and 3 were active against Conidiobolus obscurus (Entomophthoromycota; Entomophthorales); these fungal species are pathogenic. We therefore regard aphid pigments 1-4 as chemopreventive agents that aid in the resistance of infection by entomopathogenic fungi at the level of the individual aphid and/or at the species level.
从红色一枝黄花蚜虫 Uroleucon nigrotuberculatum 中分离得到 4 种红色聚酮类色素，尿黑尿酸 A（1）和 B（2）及其糖苷 3 和 4。尽管这些红色色素在完整的昆虫体内仅以糖苷 3 和 4 的形式存在，但在死亡时 3 和 4 会立即转化为苷元 1 和 2。色素 1 和 2 抑制 Lecanicillium sp.（子囊菌门：虫草科）的生长，1、2 和 3 对 Conidiobolus obscurus（真菌门： Entomophthoromycota；Entomophthorales）具有活性；这些真菌物种是致病的。因此，我们认为蚜虫色素 1-4 是化学预防剂，可帮助蚜虫个体和/或物种水平抵抗昆虫病原真菌的感染。
