Li Yang, Huang Na, Wang Chunlin, Ma Huanrong, Zhou Minyu, Lin Li, Huang Zhenhua, Sun Li, Shi Min, Liao Wangjun
Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Oncol Lett. 2018 Sep;16(3):2839-2850. doi: 10.3892/ol.2018.9019. Epub 2018 Jun 25.
Radiofrequency ablation has become an increasingly common therapeutic technique for patients with hepatocellular carcinoma or metastatic liver tumors. However, reports on the effect of percutaneous radiofrequency ablation (PRFA) on circulating tumor cells (CTCs) are limited. The present study aimed to further investigate the impacts of PRFA on the numbers and phenotypes of CTCs in patients with hepatocellular carcinoma or metastatic liver tumors. A total of 43 patients with hepatocellular carcinoma or 7 types of metastatic liver tumors were treated with PRFA. A total of 5 ml blood per sample were collected from the peripheral circulation 30 min before and 3 days after PRFA. The total number of CTCs significantly increased 3 days after PRFA, and the mesenchymal phenotype CTCs, which also increased significantly, significantly contributed to the overall increase in CTCs. Furthermore, the lymphocyte levels were significantly decreased following PRFA, and the CTC level was significantly higher in patients with decreased lymphocyte levels compared with those with increased lymphocyte levels. Liver tumor PRFA may increase the level of mesenchymal phenotype CTCs, which is significantly associated with the lymphocyte count. Factors pertaining to the performance of PRFA were also investigated in the present research, but no significant results were identified.
射频消融术已成为肝细胞癌或转移性肝肿瘤患者越来越常用的治疗技术。然而，关于经皮射频消融术（PRFA）对循环肿瘤细胞（CTC）影响的报道有限。本研究旨在进一步探讨PRFA对肝细胞癌或转移性肝肿瘤患者CTC数量和表型的影响。共有43例肝细胞癌患者或7种类型的转移性肝肿瘤患者接受了PRFA治疗。在PRFA前30分钟和后3天从外周循环中采集每个样本共5毫升血液。PRFA后3天CTC总数显著增加，间充质表型CTC也显著增加，对CTC的总体增加有显著贡献。此外，PRFA后淋巴细胞水平显著降低，淋巴细胞水平降低的患者CTC水平显著高于淋巴细胞水平升高的患者。肝肿瘤PRFA可能会增加间充质表型CTC的水平，这与淋巴细胞计数显著相关。本研究还调查了与PRFA操作相关的因素，但未发现显著结果。
