溴苯和1,2-二氯苯染毒大鼠肝毒性血液和组织参数的浓度相关变化及其相互关系

Concentration-related changes in blood and tissue parameters of hepatotoxicity and their interdependence in rats exposed to bromobenzene and 1,2-dichlorobenzene.

作者信息

Brondeau M T, Ban M, Bonnet P, Guenier J P, De Ceaurriz J

出版信息

Toxicol Lett. 1986 May;31(2):159-66. doi: 10.1016/0378-4274(86)90010-x.

Abstract

Liver damage resulting from 4 h exposure to bromobenzene (BB) (146-957 ppm) and 1,2-dichlorobenzene (DCB) (245-739 ppm) as model toxicants was evaluated in rats. The modifications considered were the increases in serum glutamate dehydrogenase (GLDH) and sorbitol dehydrogenase (SDH) activities and the decreases in centrolobular liver-cell glucose-6-phosphatase (G6-Pase) staining intensity. A linear inverse relationship was established between the logarithmic values of blood enzyme activities and liver G6-Pase staining intensity. In addition, the levels of exposure to each test chemical were found to be linearly related to liver G6-Pase staining intensity and to the logarithmic values of blood enzyme activities.

摘要

以大鼠为实验对象，评估了暴露于作为模型毒物的溴苯（BB）（146 - 957 ppm）和1,2 - 二氯苯（DCB）（245 - 739 ppm）4小时所导致的肝损伤。所考虑的变化包括血清谷氨酸脱氢酶（GLDH）和山梨醇脱氢酶（SDH）活性的升高，以及肝小叶中央区肝细胞葡萄糖 - 6 - 磷酸酶（G6 - Pase）染色强度的降低。在血液酶活性的对数值与肝脏G6 - Pase染色强度之间建立了线性反比关系。此外，发现每种受试化学物质的暴露水平与肝脏G6 - Pase染色强度以及血液酶活性的对数值呈线性相关。