Department of Epidemiology and Biostatistics, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Rehabilitation Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Curr Med Sci. 2018 Aug;38(4):602-609. doi: 10.1007/s11596-018-1920-3. Epub 2018 Aug 20.
Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated with MTHFR gene polymorphisms too. In this article, we aimed to determine the relationship between MTHFR gene polymorphisms and bone turnover rates among the pregnant women. The participants including pregnant and non-pregnant women were selected and recruited during their routine prenatal or physical examination from July to October in 2012. A total of 1000 participants, including 250 pregnant women in the first, second, and third trimesters and 250 non-pregnant women, were enrolled in the study. Finally, after excluding 27 participants unable to provide blood samples, 973 eligible participants (i.e., 234,249, and 248 pregnant women in the first, second, and third trimesters, respectively, and 242 non-pregnant women) were included in the research. The MTHFR gene 1298CC homozygote carriers were more susceptible to yield higher plasma homocysteine levels than the 1298AA/AC carriers, with standardized coefficients of 0.086 (P<0.05) and 0.104 (P<0.01) of all the participants and the pregnant women, respectively. The MTHFR gene 1793AA homozygote carriers more likely showed higher plasma osteocalcin levels (standardized β=0.091,P<0.01) than the 1793GG/GA carriers among all the subjects. Plasma homocysteine levels were positively correlated with blood lead levels among the participants and the pregnant women with standardized coefficients of 0.320 (P<0.01) and 0.179 (P<0.01), respectively. Plasma osteocalcin levels were positively associated with blood lead levels among pregnant and non-pregnant women with standardized coefficients of 0.084 (P<0.05) and 0.125 (P<0.01), respectively. In conclusion, homocysteine and osteocalcin contents in plasma are associated with the MTHFR gene A1298C polymorphism and blood lead levels among pregnant women. The MTHFR gene A1298C polymorphism-related homocysteine is a possible risk factor for increased blood lead levels among Chinese women.
妊娠是骨矿物质吸收的关键刺激因素。我们曾经发现 MTHFR 基因突变与孕妇的血铅水平有关。妊娠刺激的骨转换也可能与 MTHFR 基因突变有关。在本文中，我们旨在确定 MTHFR 基因突变与孕妇骨转换率之间的关系。我们在 2012 年 7 月至 10 月期间，从常规产前或体检中选择和招募了孕妇和非孕妇作为研究对象。共有 1000 名参与者，包括 250 名处于第一、二、三期妊娠的孕妇和 250 名非孕妇，参与了这项研究。最终，在排除了 27 名无法提供血液样本的参与者后，973 名符合条件的参与者（即第一、二、三期妊娠的孕妇分别为 234、249 和 248 名，非孕妇为 242 名）被纳入研究。MTHFR 基因 1298CC 纯合子携带者比 1298AA/AC 携带者更容易产生更高的血浆同型半胱氨酸水平，所有参与者和孕妇的标准化系数分别为 0.086（P<0.05）和 0.104（P<0.01）。MTHFR 基因 1793AA 纯合子携带者的血浆骨钙素水平高于 1793GG/GA 携带者（标准化β=0.091，P<0.01）。所有受试者中，血浆同型半胱氨酸水平与血铅水平呈正相关，标准化系数为 0.320（P<0.01）；孕妇中，血浆同型半胱氨酸水平与血铅水平呈正相关，标准化系数为 0.179（P<0.01）。孕妇和非孕妇的血浆骨钙素水平与血铅水平呈正相关，标准化系数分别为 0.084（P<0.05）和 0.125（P<0.01）。综上所述，孕妇血浆同型半胱氨酸和骨钙素含量与 MTHFR 基因 A1298C 多态性和血铅水平有关。MTHFR 基因 A1298C 多态性相关的同型半胱氨酸可能是中国女性血铅水平升高的一个潜在危险因素。
