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[鲍温样丘疹病及其与鲍恩病和非典型湿疣的关系]

[Bowenoid papulosis and its relation to Bowen's disease and atypical condyloma].

作者信息

Jabłónska S, Obalek S, Orth G

出版信息

Z Hautkr. 1986 Apr 15;61(8):563-5.

PMID:3012895
Abstract

All the 5 sexual partners of male patients suffering from bowenoid papulosis and bearing the HPV 16 genome showed cervical lesions induced by HPV. 2 of them proved to be noncondylomatous infections, 3 cases were cervical condylomas, and 2 patients revealed severe dysplasia or carcinoma in situ (CIS). 3 out of 4 women suffering from multicentrical pigmented Bowen's disease of the vulva showed plain condylomas of the cervix, with severe dysplasia or CIS in 2 cases and slight dysplasia in one case. Thus bowenoid papulosis as well as multicentrical pigmented Bowen's disease of the vulva are high risk factors for cervical HPV infection and carcinoma, both for the patients themselves and their sexual partners. Atypical pigmented genital condylomas induced by HPV 6 also bear a risk for cervical HPV infection of the sexual partners. Malignant transformation, however, seems to depend on the type of the infecting virus (mainly HPV 16).

摘要

患有鲍温样丘疹病且携带人乳头瘤病毒16型基因组的男性患者的所有5名性伴侣均出现了由人乳头瘤病毒引起的宫颈病变。其中2例被证实为非尖锐湿疣感染,3例为宫颈尖锐湿疣,2例患者出现严重发育异常或原位癌(CIS)。4名患有外阴多中心色素沉着性鲍温病的女性中,有3例表现为宫颈单纯尖锐湿疣,2例有严重发育异常或原位癌,1例有轻度发育异常。因此,鲍温样丘疹病以及外阴多中心色素沉着性鲍温病对于患者自身及其性伴侣而言,都是宫颈人乳头瘤病毒感染和癌症的高危因素。由人乳头瘤病毒6型引起的非典型色素沉着性生殖器尖锐湿疣也会使性伴侣有宫颈人乳头瘤病毒感染的风险。然而,恶性转化似乎取决于感染病毒的类型(主要是人乳头瘤病毒16型)。

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