Haratake J, Horie A, Higashi T
Acta Pathol Jpn. 1986 Mar;36(3):439-47. doi: 10.1111/j.1440-1827.1986.tb01033.x.
Histochemical and ultrastructural features of a gastric myxoid leiomyosarcoma from a 55-year-old man were examined. At autopsy, the tumor was located mainly in the greater omentum and was directly connected to a coinsized gastric tumor. Multiple hepatic metastases and peritoneal disseminations were noted. Light-microscopically, the tumor was composed of a prominent myxoid stroma and ovoid or rounded tumor cells. The myxoid stroma was stained weakly basophilic with hematoxylin and eosin, and was mainly composed of hyaluronic acid. Tumor cells in the stomach were spindle-shaped and apparently myogenic. Ultrastructurally, the gastric tumor cells showed a loose cohesion with junctional apparatuses, pinocytotic vesicles, basal laminae, and cytoplasmic filaments with focal densities. Tumor cells in the omentum and the liver, however, were poorly differentiated and showed an epithelioid nature in part. This unique leiomyosarcoma is reported with some differential diagnoses from other myxoid sarcomas.
对一名55岁男性的胃黏液样平滑肌肉瘤的组织化学和超微结构特征进行了检查。尸检时，肿瘤主要位于大网膜，与一枚硬币大小的胃肿瘤直接相连。发现有多处肝转移和腹膜播散。光镜下，肿瘤由显著的黏液样间质和卵圆形或圆形肿瘤细胞组成。黏液样间质苏木精-伊红染色呈弱阳性，主要由透明质酸组成。胃内的肿瘤细胞呈梭形，明显具有肌源性。超微结构上，胃肿瘤细胞与连接装置、吞饮小泡、基膜和有局灶性致密物的细胞质细丝之间的黏附松散。然而，大网膜和肝脏中的肿瘤细胞分化较差，部分表现出上皮样特征。本文报道了这种独特的平滑肌肉瘤，并与其他黏液样肉瘤进行了一些鉴别诊断。
