Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Natl Med Assoc. 2018 Dec;110(6):534-539. doi: 10.1016/j.jnma.2018.01.005. Epub 2018 Feb 15.
Increased photoprotection by natural melanin allows for African-Americans to be less impacted by photoaging than Caucasians. However, less is known about chronological aging in this population.
To create a photonumeric scale for African-Americans to evaluate chronological skin aging and to explore contributing elements to intrinsic aging.
Standardized photographs of the upper inner arm were taken from 75 African-American participants. Five participants were chosen as standards to create a 9-point photonumeric scale (0 = none, 8 = most severe). The scale was utilized by three blinded dermatologists to independently rate participants' photographs.
The interrater agreements were 0.768 (95% CI: 0.671-0.834) for trial 1 and 0.725 (0.608-0.794) for trial 2. The intrarater agreements were 0.757 (0.596-0.875), 0.850 (0.771-0.903), and 0.790 (0.686-0.855) for the three raters. Averaged chronological aging scores were correlated with participants' survey responses, which revealed age as a significant predictor (r = 0.72, p < 0.001).
Our study was limited by the sample size, although the number of study participants was similar on a investigation in Caucasians.
This study created the first reliable photonumeric scale for chronologic skin aging in African-Americans and found increased age and greater BMI as contributors to intrinsic skin aging phenotype in this population.
由于天然黑色素能增强防晒能力,非裔美国人受光老化的影响比白种人小。然而,关于这个人群的自然老化,人们知之甚少。
为非裔美国人创建一个光数字量表来评估皮肤的自然老化,并探讨内在老化的促成因素。
从 75 名非裔美国参与者的上内臂拍摄标准化照片。选择 5 名参与者作为标准,创建一个 9 分光数字量表(0=无,8=最严重)。三位盲评皮肤科医生使用该量表独立评估参与者的照片。
在试验 1 中,三位盲评皮肤科医生的组间一致性为 0.768(95%CI:0.671-0.834),在试验 2 中为 0.725(0.608-0.794)。三位盲评皮肤科医生的组内一致性分别为 0.757(0.596-0.875)、0.850(0.771-0.903)和 0.790(0.686-0.855)。平均的自然老化评分与参与者的调查回答相关,结果显示年龄是非裔美国人自然老化的一个显著预测因素(r=0.72,p<0.001)。
本研究受到样本量的限制,尽管研究参与者的数量与白种人的研究相似。
本研究为非裔美国人的皮肤自然老化创建了第一个可靠的光数字量表,并发现年龄增长和 BMI 增加是非裔美国人自然老化表型的促成因素。