College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Mol Omics. 2018 Oct 8;14(5):341-351. doi: 10.1039/c8mo00128f.
Ovarian cancer is one of the leading causes of death from gynecologic malignancy in women. High-grade serous carcinomas, low-grade serous carcinomas, endometrioid carcinomas, clear cell carcinomas, and mucinous carcinomas with distinct pathological and clinical characteristics are the main histological subtypes of ovarian cancer. The majority of ovarian cancer patients are diagnosed at an advanced stage due to a lack of suitable screening tests for early detection and specific early symptoms. Despite progress in therapy improvements in ovarian cancer, most patients develop a recurrence within months or years after initial treatment. Given that the presence of tumor infiltrating lymphocytes is associated with prognosis and ovarian cancer is among the first cancers with an established association of immune cell infiltration, identification of the immune microenvironment in ovarian cancer is thought to be promising. In this study, to increase the understanding of tumor immune cell interactions, we undertook a study of tumor infiltrating lymphocytes in a large group of ovarian cancer patients. Our results suggested that tumor immune infiltrates of ovarian cancer were quite cohort and subtype dependent, and activated CD4+ T and CD8+ T tumor infiltrating lymphocytes were associated with good overall survival in the high-grade serous tumors. We found that high expression levels of the immune-related genes were associated with good prognosis in high-grade serous carcinomas. In addition, two different groups of prognostic genes were found in the high-grade and low-grade serous carcinomas, indicating that these two subtypes of serous carcinomas were two biologically and clinically different cancer types.
卵巢癌是导致女性妇科恶性肿瘤死亡的主要原因之一。高级别浆液性癌、低级别浆液性癌、子宫内膜样癌、透明细胞癌和黏液性癌，具有不同的病理和临床特征，是卵巢癌的主要组织学亚型。由于缺乏合适的筛查试验来进行早期检测和特定的早期症状，大多数卵巢癌患者在诊断时已处于晚期。尽管在治疗方面取得了进展，但在初始治疗后数月或数年内，大多数患者仍会复发。鉴于肿瘤浸润淋巴细胞的存在与预后相关，并且卵巢癌是首批确定与免疫细胞浸润相关的癌症之一，因此认为鉴定卵巢癌的免疫微环境具有广阔的前景。在这项研究中，为了增进对肿瘤免疫细胞相互作用的理解，我们对一大群卵巢癌患者的肿瘤浸润淋巴细胞进行了研究。我们的研究结果表明，卵巢癌的肿瘤免疫浸润具有很强的队列和亚型依赖性，并且在高级别浆液性肿瘤中，活化的 CD4+T 和 CD8+T 肿瘤浸润淋巴细胞与良好的总生存率相关。我们发现，免疫相关基因的高表达水平与高级别浆液性癌的良好预后相关。此外，在高级别和低级别浆液性癌中发现了两组不同的预后基因，这表明这两种浆液性癌亚型是两种生物学和临床上不同的癌症类型。
