Sun Lei, Wang Yan-juan, Hu Yuan, Cao Sheng-kui, Shen Yu-juan, Cao Jian-ping
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2016 Oct;34(5):414-7.
To examine the IgG and IgM antibodies for parasites Cysticercus cellulosae and Toxoplasma gondii in 122 patients with meningitis encephalitis syndrome, and provide basis for clinical diagnosis of the meningitis encephalitis syndrome.
The sera were collected from patients with meningitis encephalitis syndrome in Shanghai Jiaotong University Affiliated Sixth People’s Hospital, People’s Hospital of Danyang City, and Jiangsu University Affiliated Hospital from August, 2014 to December, 2015. Serum IgG and IgM antibodies for cysticercus and T. gondii were examined using antibody test kits. The antibody positive rate was calculated and its distribution was analyzed by gender, season, age and occupation.
A total of 122 patients with meningitis encephalitis syndrome were included. Seventeen and 22 patients of them were positive for IgG （13.9%, 17/122） and IgM（18.0%, 22/122） against cysticercus, respectively, while 29 and 8 cases were positive for IgG （23.8%, 29/122） and IgM （6.6%, 8/122） against T. gondii. The positive rate of cysticercus and T. gondii in males was 30.6%（22/72） and 31.9%（23/72） respectively, while that in females was 26.0%（13/50） and 24.0% （12/50）. The positive rate of IgM against cysticercus was 12.0%（3/25）, 27.0%（17/63）, 6.9% （2/29）, and 0（0/5） from spring to winter, highest within 13-25 years（45.0%, 9/20） among age groups, and highest in workers（7/14） among various occupations. The positive rate of IgM against T. gondii was 4.0%（1/25）, 11.1% （7/63）, 0（0/29）, and 0（0/5） from spring to winter, highest in ages >65 years（44.0%, 11/25）, and highest in patients with other occupations（4/10）. There was no statistically significant difference in the positive rate between males and females, and among different seasons, ages and occupations.
The positive rate of antibodies against cysticercus and T. gondii is high in the patients included, suggesting that a serological test for parasite infection might be performed during clinical diagnosis of meningitis encephalitis syndrome.
检测122例脑膜脑炎综合征患者血清中抗猪囊尾蚴和弓形虫的IgG及IgM抗体，为脑膜脑炎综合征的临床诊断提供依据。
收集2014年8月至2015年12月上海交通大学附属第六人民医院、丹阳市人民医院及江苏大学附属医院脑膜脑炎综合征患者的血清。采用抗体检测试剂盒检测血清中抗囊尾蚴和弓形虫的IgG及IgM抗体。计算抗体阳性率，并分析其在性别、季节、年龄和职业方面的分布情况。
共纳入122例脑膜脑炎综合征患者。其中抗囊尾蚴IgG阳性17例（13.9%，17/122），IgM阳性22例（18.0%，22/122）；抗弓形虫IgG阳性29例（23.8%，29/122），IgM阳性8例（6.6%，8/122）。男性抗囊尾蚴和弓形虫的阳性率分别为30.6%（22/72）和31.9%（23/72），女性分别为26.0%（13/50）和24.0%（12/50）。抗囊尾蚴IgM阳性率从春季到冬季依次为12.0%（3/25）、27.0%（17/63）、6.9%（2/29）和0（0/5），年龄组中13 - 25岁最高（45.0%，9/20），职业中工人最高（7/14）。抗弓形虫IgM阳性率从春季到冬季依次为4.0%（1/25）、11.1%（7/63）、0（0/29）和0（0/5），年龄>65岁最高（44.0%，11/25），职业中其他职业患者最高（4/10）。男女之间、不同季节、年龄和职业的阳性率差异均无统计学意义。
纳入患者中抗囊尾蚴和弓形虫抗体阳性率较高，提示在脑膜脑炎综合征临床诊断时可进行寄生虫感染的血清学检测。
