Sundberg J P, O'Banion M K, Schmidt-Didier E, Reichmann M E
Am J Vet Res. 1986 May;47(5):1142-4.
A papillomavirus, isolated from oral papillomas in young Beagles, was used to produce a live-virus vaccine. After the IM use of this vaccine, some dogs developed squamous cell carcinomas at the inoculation site. The virus was isolated from the original vaccine and was cloned into pBR322. A detailed restriction map of the viral genome was generated.
从幼年比格犬口腔乳头瘤中分离出的一种乳头瘤病毒被用于生产一种活病毒疫苗。在肌肉注射这种疫苗后，一些犬在接种部位发生了鳞状细胞癌。该病毒从原始疫苗中分离出来，并克隆到pBR322中。生成了病毒基因组的详细限制性图谱。
