Bigliardi Paul L
Curr Probl Dermatol. 2018;54:108-114. doi: 10.1159/000489524. Epub 2018 Aug 21.
Not much is known about the role of skin pH in skin pathophysiology, in particular in psoriasis. However, there is compelling evidence that the epidermal pH can influence the skin homeostasis and affect the skin barrier by changing the activity of cutaneous enzymes and through the modulation of skin inflammation and microbial colonization. This includes the activation of secretory phospholipase A and interaction with the peroxisome proliferators-activated receptor and retinoid pathways. In addition, pH in skin affects the activity of aquaporins and this controls the hydration of the epidermis. Changes in skin homeostasis, differentiation, barrier defects, and inflammation play a crucial role in the pathogenesis of psoriasis. There is evidence that skin pH can affect all of these important factors. However, more studies are needed to examine objectively and precisely the pH in the various skin layers in psoriatic lesional and non-lesional skin and compare it to normal skin. This additional know-how is essential to understand the role of skin pH in psoriasis with ultimately great potential of manipulations of skin pH for topical approaches in the management of psoriasis.
关于皮肤pH值在皮肤病理生理学中的作用，尤其是在银屑病中的作用，目前所知甚少。然而，有确凿证据表明，表皮pH值可通过改变皮肤酶的活性以及调节皮肤炎症和微生物定植来影响皮肤稳态并影响皮肤屏障。这包括分泌型磷脂酶A的激活以及与过氧化物酶体增殖物激活受体和类维生素A途径的相互作用。此外，皮肤中的pH值会影响水通道蛋白的活性，进而控制表皮的水合作用。皮肤稳态、分化、屏障缺陷和炎症的变化在银屑病的发病机制中起着关键作用。有证据表明皮肤pH值会影响所有这些重要因素。然而，需要更多研究来客观、精确地检测银屑病皮损和非皮损皮肤各层的pH值，并与正常皮肤进行比较。这些额外的知识对于理解皮肤pH值在银屑病中的作用至关重要，最终对于通过调节皮肤pH值进行银屑病局部治疗具有巨大潜力。
