Kimura H, Yamaguchi Y, Kadoyama C, Matsumoto A
Gan To Kagaku Ryoho. 1986 Jun;13(6):2175-81.
The cytotoxicity of lymphocytes against autologous cultured primary lung cancer cells was examined. A total of 88 patients aged from 34 to 81 years, 71 males and 17 females, were evaluated. These consisted of adenocarcinoma (n = 42), squamous cell carcinoma (n = 33), large cell carcinoma (n = 5), small cell carcinoma (n = 5), carcinoid (n = 2) and primary lung sarcoma (n = 1) cases. There was no correlation between cytotoxicity and age, or with disease stage. The mean values of the cytotoxicities of adenocarcinoma, squamous cell carcinoma, large cell carcinoma and small cell carcinoma, were 33.9%, 32.5%, 21.6% and 3.5%, respectively. By tentatively defining cases with a cytotoxicity exceeding 15% as positive, the percentage positive rates of each of the four most common histological types were 71.4%, 75.8%, 60.0% and 20.0%, respectively. The mean value of cytotoxicity and the percentage positive rate of small cell carcinoma cases were lower than those of both adenocarcinoma and squamous cell carcinoma. When the patients were divided into 3 groups according to their N (lymph node) and T (Tumor) factor, a significant difference was recognized. That is, the mean value of cytotoxicity and percentage positive rate of the group in which the N factor exceeded the T factor minus 1, such as T1N2, T1N1 and T2N2 (N-predominant group), were significantly lower than those of the group in which the T factor minus 1 exceeded the N factor, such as T3N0, T3N1 and T2N0 (T-predominant group) and the intermittent group (T3N2, T2N1 and T1N0).
检测了淋巴细胞对自体培养的原发性肺癌细胞的细胞毒性。共评估了88例年龄在34至81岁之间的患者，其中男性71例，女性17例。这些病例包括腺癌（n = 42）、鳞状细胞癌（n = 33）、大细胞癌（n = 5）、小细胞癌（n = 5）、类癌（n = 2）和原发性肺肉瘤（n = 1）。细胞毒性与年龄或疾病分期之间无相关性。腺癌、鳞状细胞癌、大细胞癌和小细胞癌的细胞毒性平均值分别为33.9%、32.5%、21.6%和3.5%。通过初步将细胞毒性超过15%的病例定义为阳性，四种最常见组织学类型的阳性率分别为71.4%、75.8%、60.0%和20.0%。小细胞癌病例的细胞毒性平均值和阳性率低于腺癌和鳞状细胞癌。当根据患者的N（淋巴结）和T（肿瘤）因子将患者分为3组时，发现了显著差异。也就是说，N因子超过T因子减1的组，如T1N2、T1N1和T2N2（N为主组）的细胞毒性平均值和阳性率，显著低于T因子减1超过N因子的组，如T3N0、T3N1和T2N0（T为主组）以及中间组（T3N2、T2N1和T1N0）。
