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A A Pract. 2018 Jul 15;11(2):46-48. doi: 10.1213/XAA.0000000000000734.
2
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS.美国临床内分泌医师协会和美国内分泌学会关于钠-葡萄糖协同转运蛋白2(SGLT-2)抑制剂与糖尿病酮症酸中毒相关性的立场声明
Endocr Pract. 2016 Jun;22(6):753-62. doi: 10.4158/EP161292.PS. Epub 2016 Jun 1.
3
Euglycemic diabetic ketoacidosis induced by SGLT2 inhibitors: possible mechanism and contributing factors.钠-葡萄糖协同转运蛋白2抑制剂诱导的正常血糖性糖尿病酮症酸中毒:可能机制及影响因素
J Diabetes Investig. 2016 Mar;7(2):135-8. doi: 10.1111/jdi.12401. Epub 2015 Sep 6.
4
Normoglycemic ketoacidosis in a postoperative gastric bypass patient taking canagliflozin.
Surg Obes Relat Dis. 2016 Jan;12(1):e11-2. doi: 10.1016/j.soard.2015.08.502. Epub 2015 Aug 18.
5
Peri-operative management of the surgical patient with diabetes 2015: Association of Anaesthetists of Great Britain and Ireland.2015年糖尿病外科患者围手术期管理:大不列颠及爱尔兰麻醉医师协会
Anaesthesia. 2015 Dec;70(12):1427-40. doi: 10.1111/anae.13233. Epub 2015 Sep 29.
6
Euglycemic Diabetic Ketoacidosis: A Predictable, Detectable, and Preventable Safety Concern With SGLT2 Inhibitors.正常血糖性糖尿病酮症酸中毒:SGLT2抑制剂相关的可预测、可检测且可预防的安全问题
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7
Diabetic Ketoacidosis and Related Events in the Canagliflozin Type 2 Diabetes Clinical Program.卡格列净治疗2型糖尿病临床项目中的糖尿病酮症酸中毒及相关事件
Diabetes Care. 2015 Sep;38(9):1680-6. doi: 10.2337/dc15-1251. Epub 2015 Jul 22.
8
Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery.肥胖与代谢外科医师协会、美国临床内分泌医师协会、美国肥胖学会 2013 年肥胖病与代谢外科围手术期营养、代谢及非手术支持治疗临床实践指南更新版
Obesity (Silver Spring). 2013 Mar;21 Suppl 1(0 1):S1-27. doi: 10.1002/oby.20461.

接受卡格列净治疗的2型糖尿病肥胖手术患者的正常血糖性糖尿病酮症酸中毒

Euglycaemic diabetic ketoacidosis in bariatric surgery patients with type 2 diabetes taking canagliflozin.

作者信息

van Niekerk Christoffel, Wallace James, Takata Mark, Yu Roger

机构信息

Department of Internal Medicine, Scripps Clinic - Scripps Green Hospital, La Jolla, California, USA.

出版信息

BMJ Case Rep. 2018 Aug 20;2018:bcr-2017-221527. doi: 10.1136/bcr-2017-221527.

DOI:10.1136/bcr-2017-221527
PMID:30131409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6109719/
Abstract

A 52-year-old type 2 diabetic man previously on canagliflozin developed severe anion gap metabolic acidosis and markedly elevated beta-hydroxybutyrate on postoperative day (POD) 2 status post laparoscopic Roux-en-Y gastric bypass. An insulin drip and aggressive intravenous fluid repletion were initiated, and electrolytes were monitored and repleted. His anion gap closed, and he was discharged on POD 4. This euglycaemic diabetic ketoacidosis prolonged his hospital stay by 2 days.

摘要

一名52岁的2型糖尿病男性患者,此前服用卡格列净,在接受腹腔镜Roux-en-Y胃旁路手术后第2天(术后日,POD)出现严重阴离子间隙代谢性酸中毒,β-羟丁酸水平显著升高。开始静脉输注胰岛素并积极补充静脉液体,同时监测并补充电解质。他的阴离子间隙恢复正常,于术后第4天出院。这种正常血糖性糖尿病酮症酸中毒使他的住院时间延长了2天。