• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人类载脂蛋白CI（apo CI）在19号染色体上有两个基因序列，其中一个距apo E基因4千碱基对。

There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E.

作者信息

Davison P J, Norton P, Wallis S C, Gill L, Cook M, Williamson R, Humphries S E

出版信息

Biochem Biophys Res Commun. 1986 May 14;136(3):876-84. doi: 10.1016/0006-291x(86)90414-6.

DOI:10.1016/0006-291x(86)90414-6
PMID:3013172
Abstract

A cDNA probe corresponding to the mRNA sequence for apolipoprotein E (apo E) was used to screen two independently-constructed human genomic libraries. Two recombinants (lambda E-2, and lambda E2-1), isolated using the apo E cDNA probe, also contain part or all of the apo CI gene. Hybridisation studies using both apo E and apo CI cDNA probes show that these two genes are in the same orientation and separated by 4 kb.

摘要

使用与载脂蛋白E（apo E）mRNA序列相对应的cDNA探针筛选两个独立构建的人类基因组文库。用apo E cDNA探针分离得到的两个重组体（λE - 2和λE2 - 1）也包含部分或全部的apo CI基因。使用apo E和apo CI cDNA探针进行的杂交研究表明，这两个基因方向相同，间隔4 kb。

相似文献

1
There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E.人类载脂蛋白CI（apo CI）在19号染色体上有两个基因序列，其中一个距apo E基因4千碱基对。
Biochem Biophys Res Commun. 1986 May 14;136(3):876-84. doi: 10.1016/0006-291x(86)90414-6.
2
Two coding regions closely linked to the rat apolipoprotein E gene: nucleotide sequences of rat apolipoprotein C-I and ECL cDNA.与大鼠载脂蛋白E基因紧密连锁的两个编码区：大鼠载脂蛋白C-I和ECL cDNA的核苷酸序列
Arch Biochem Biophys. 1992 Sep;297(2):345-53. doi: 10.1016/0003-9861(92)90683-n.
3
The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19.人类载脂蛋白CI基因位于19号染色体上，距离载脂蛋白E基因4.3千碱基处。
Hum Genet. 1986 Aug;73(4):286-9. doi: 10.1007/BF00279087.
4
Chromosomal localization of the human apoprotein CI gene and of a polymorphic apoprotein AII gene.人类载脂蛋白CI基因和多态性载脂蛋白AII基因的染色体定位。
Biochem Biophys Res Commun. 1984 Nov 30;125(1):299-306. doi: 10.1016/s0006-291x(84)80368-x.
5
Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes.
J Biol Chem. 1985 Dec 5;260(28):15222-31.
6
The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes.
J Biol Chem. 1985 Dec 5;260(28):15211-21.
7
The baboon apolipoprotein E gene: structure, expression, and linkage with the gene for apolipoprotein C-1.狒狒载脂蛋白E基因：结构、表达及其与载脂蛋白C-1基因的连锁关系。
Genomics. 1988 May;2(4):315-23. doi: 10.1016/0888-7543(88)90020-1.
8
Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19.人载脂蛋白CI cDNA克隆的分离、鉴定及该基因在19号染色体上的定位
Hum Genet. 1985;69(4):345-9. doi: 10.1007/BF00291654.
9
Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.人类载脂蛋白E基因的分离、特性鉴定及其在19号染色体上的定位
J Biol Chem. 1985 May 25;260(10):6240-7.
10
Evolution of the apolipoproteins. Structure of the rat apo-A-IV gene and its relationship to the human genes for apo-A-I, C-III, and E.载脂蛋白的进化。大鼠载脂蛋白A-IV基因的结构及其与人类载脂蛋白A-I、C-III和E基因的关系。
J Biol Chem. 1986 May 15;261(14):6398-407.

引用本文的文献

1
Role of apolipoprotein C1 in lipoprotein metabolism, atherosclerosis and diabetes: a systematic review.载脂蛋白 C1 在脂蛋白代谢、动脉粥样硬化和糖尿病中的作用：系统评价。
Cardiovasc Diabetol. 2022 Dec 5;21(1):272. doi: 10.1186/s12933-022-01703-5.
2
Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study.人载脂蛋白 E 上隐藏的聚集热点：一项结构研究。
Int J Mol Sci. 2019 May 8;20(9):2274. doi: 10.3390/ijms20092274.
3
Proteogenomic Review of the Changes in Primate apoC-I during Evolution.灵长类动物载脂蛋白C-I在进化过程中变化的蛋白质基因组学综述
Front Biol (Beijing). 2013 Oct;8(5):533-548. doi: 10.1007/s11515-013-1278-7. Epub 2013 Oct 2.
4
Tight linkage between myotonic dystrophy and apolipoprotein E genes revealed with allele-specific oligonucleotides.
Hum Genet. 1988 Sep;80(1):49-52. doi: 10.1007/BF00451455.
5
A physical map of the apolipoprotein gene cluster on human chromosome 19.人类第19号染色体上载脂蛋白基因簇的物理图谱。
Hum Genet. 1988 Mar;78(3):244-7. doi: 10.1007/BF00291670.
6
Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia.
Hum Genet. 1988 Jan;78(1):90-3. doi: 10.1007/BF00291243.
7
A common restriction fragment length polymorphism of the human apolipoprotein E gene and its relationship to type III hyperlipidaemia.人类载脂蛋白E基因常见的限制性片段长度多态性及其与Ⅲ型高脂血症的关系。
Hum Genet. 1987 Mar;75(3):244-7. doi: 10.1007/BF00281067.
8
Apolipoprotein (apo) E genotypes by polymerase chain reaction and allele-specific oligonucleotide probes: no detectable linkage disequilibrium between apo E and apo CII.
Hum Genet. 1989 Nov;83(4):364-8. doi: 10.1007/BF00291382.
9
Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy.载脂蛋白C1基因和细胞色素P450基因（CYP2A）与强直性肌营养不良的连锁关系。
Hum Genet. 1990 Aug;85(3):305-10. doi: 10.1007/BF00206751.