Raptis L, Boynton A L, Whitfield J F
Biochem Biophys Res Commun. 1986 May 14;136(3):995-1000. doi: 10.1016/0006-291x(86)90431-6.
Stimulation of protein kinase C in polyoma virus-transformed cells increased the phosphorylation of tyrosine residues of the viral middle T (mT) antigen in mT:pp60c-src complexes precipitated by anti-mT antibodies. This increase might have been due to a stimulation of the complex's pp60c-src tyrosine kinase activity or to an increased ability of the mT protein to be phosphorylated by pp60c-src. These observations suggest that cellular protein kinase C might control the ability of polyoma virus to transform its host cell.
在多瘤病毒转化细胞中，蛋白激酶C的激活增加了抗mT抗体沉淀的mT:pp60c-src复合物中病毒中T（mT）抗原酪氨酸残基的磷酸化。这种增加可能是由于复合物的pp60c-src酪氨酸激酶活性受到刺激，或者是由于mT蛋白被pp60c-src磷酸化的能力增强。这些观察结果表明，细胞蛋白激酶C可能控制多瘤病毒转化其宿主细胞的能力。
