三氯甲烷作为一氧化碳源在钯催化合成 2-酰胺基咪唑并[1,2-a]吡啶中的应用。
Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines.
机构信息
National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvananthapuram-19, India.
出版信息
Org Biomol Chem. 2018 Sep 11;16(35):6430-6437. doi: 10.1039/c8ob01486h.
PMID:30132779
Abstract
A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically potent 2-amidoimidazopyridine scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biological evaluation of cytotoxicity on selected examples provides scope for future investigations.
摘要
开发了一种钯催化的利用氯仿作为 CO 源的氨基甲酰化策略，用于合成具有生物活性的 2-酰胺基咪唑并吡啶支架。该氨基甲酰化反应具有广泛的胺和取代的咪唑并吡啶的通用性。对选定实例的细胞毒性的初步生物学评估为进一步研究提供了空间。
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