Zhou Yong-hua, Yang Ying-ying, Fan Xiao-lin, Sai Xue
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2017 Feb;35(1):89-92.
Liver fibrosis in schistosomiasis is a serious pathological consequence from immune reactions to schistosome infection. The progression of liver fibrosis depends on the state of immune response. Recent studies have found that Th17 and Treg cells are two subsets of CD4+T cells. The Th17 cells are mainly involved in inflammatory responses, while the Treg cells mainly mediate downregulation of the responses. Under normal conditions, the differentiations of the two subsets are inhibited by each other, and they function oppositely. The balance between Th17 and Treg cells, as well as the balance between them, play an important role in the maintenance of homeostasis and are involved in inflammatory responses, tissue trauma, fibrosis and development of many diseases. This paper reviews the role of Th17/Treg cells and their imbalance in liver fibrosis in schistosomiasis.
血吸虫病中的肝纤维化是对血吸虫感染免疫反应的严重病理后果。肝纤维化的进展取决于免疫反应的状态。最近的研究发现，Th17细胞和调节性T（Treg）细胞是CD4 + T细胞的两个亚群。Th17细胞主要参与炎症反应，而Treg细胞主要介导反应的下调。在正常情况下，这两个亚群的分化相互抑制，且功能相反。Th17细胞和Treg细胞之间的平衡以及它们之间的平衡在维持体内稳态中起重要作用，并参与炎症反应、组织创伤、纤维化以及许多疾病的发展。本文综述了Th17/Treg细胞及其失衡在血吸虫病肝纤维化中的作用。
