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PharmGKB summary: clozapine pathway, pharmacokinetics.

作者信息

Thorn Caroline F, Müller Daniel J, Altman Russ B, Klein Teri E

机构信息

Departments of Biomedical Data Sciences.

Pharmacogenetics Research Clinic, Centre for Addiction and Mental Health.

出版信息

Pharmacogenet Genomics. 2018 Sep;28(9):214-222. doi: 10.1097/FPC.0000000000000347.

DOI:10.1097/FPC.0000000000000347
PMID:30134346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6449846/
Abstract
摘要

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Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors.氯氮平生物转化途径在人肝微粒体中对 CYP1A2 和 CYP3A4 选择性抑制剂反应的差异。
Basic Clin Pharmacol Toxicol. 2018 Apr;122(4):388-395. doi: 10.1111/bcpt.12933. Epub 2017 Dec 15.
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Plasma ratio of clozapine to N-desmethylclozapine can predict cognitive performance in treatment-resistant psychotic patients.氯氮平与 N-去甲基氯氮平的血浆比值可预测抗精神病药物治疗抵抗的精神病患者的认知表现。
Psychiatry Res. 2017 Dec;258:153-157. doi: 10.1016/j.psychres.2017.10.010. Epub 2017 Oct 3.
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转录因子核因子1 B T>C多态性对氯氮平体内代谢及体外肠道转运体表达的影响。
Drug Metab Dispos. 2025 Jul;53(7):100100. doi: 10.1016/j.dmd.2025.100100. Epub 2025 May 20.
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Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.《分子精神病学的翻译：从生物标志物到个性化疗法——一篇叙述性综述》
Int J Mol Sci. 2025 May 1;26(9):4285. doi: 10.3390/ijms26094285.
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EBioMedicine. 2025 Jun;116:105745. doi: 10.1016/j.ebiom.2025.105745. Epub 2025 May 9.
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PLoS One. 2025 Mar 6;20(3):e0319037. doi: 10.1371/journal.pone.0319037. eCollection 2025.
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