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PharmGKB summary: clozapine pathway, pharmacokinetics.

作者信息

Thorn Caroline F, Müller Daniel J, Altman Russ B, Klein Teri E

机构信息

Departments of Biomedical Data Sciences.

Pharmacogenetics Research Clinic, Centre for Addiction and Mental Health.

出版信息

Pharmacogenet Genomics. 2018 Sep;28(9):214-222. doi: 10.1097/FPC.0000000000000347.

DOI:10.1097/FPC.0000000000000347
PMID:30134346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6449846/
Abstract
摘要

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Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors.氯氮平生物转化途径在人肝微粒体中对 CYP1A2 和 CYP3A4 选择性抑制剂反应的差异。
Basic Clin Pharmacol Toxicol. 2018 Apr;122(4):388-395. doi: 10.1111/bcpt.12933. Epub 2017 Dec 15.
2
Plasma ratio of clozapine to N-desmethylclozapine can predict cognitive performance in treatment-resistant psychotic patients.氯氮平与 N-去甲基氯氮平的血浆比值可预测抗精神病药物治疗抵抗的精神病患者的认知表现。
Psychiatry Res. 2017 Dec;258:153-157. doi: 10.1016/j.psychres.2017.10.010. Epub 2017 Oct 3.
3
ABCB1 and ABCC1 single-nucleotide polymorphisms in patients treated with clozapine.接受氯氮平治疗患者的ABCB1和ABCC1单核苷酸多态性
Pharmgenomics Pers Med. 2017 Aug 28;10:235-242. doi: 10.2147/PGPM.S142314. eCollection 2017.
4
Effects of adjunctive fluvoxamine on metabolic parameters and psychopathology in clozapine-treated patients with schizophrenia: A 12-week, randomized, double-blind, placebo-controlled study.氟伏沙明辅助治疗对氯氮平治疗的精神分裂症患者代谢参数和精神病理学的影响：一项为期 12 周、随机、双盲、安慰剂对照研究。
Schizophr Res. 2018 Mar;193:126-133. doi: 10.1016/j.schres.2017.06.030. Epub 2017 Jul 6.
5
CYP2C19*17 protects against metabolic complications of clozapine treatment.CYP2C19*17 可预防氯氮平治疗的代谢并发症。
World J Biol Psychiatry. 2017 Oct;18(7):521-527. doi: 10.1080/15622975.2017.1347712. Epub 2017 Jul 18.
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Treatment With Antipsychotics in Pregnancy: Changes in Drug Disposition.妊娠期抗精神病药物治疗：药物处置的变化。
Clin Pharmacol Ther. 2018 Mar;103(3):477-484. doi: 10.1002/cpt.770. Epub 2017 Sep 19.
7
»Treatment Resistance« Enigma Resolved by Pharmacogenomics - A Case Study of Clozapine Therapy in Schizophrenia.药物基因组学解开“治疗抵抗”之谜——氯氮平治疗精神分裂症的案例研究
J Med Biochem. 2015 Apr;34(2):223-227. doi: 10.2478/jomb-2014-0041. Epub 2015 Mar 3.
8
Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics.患者 CYP3A 状态在氯氮平药代动力学中的潜在作用。
Int J Neuropsychopharmacol. 2017 Jul 1;20(7):529-537. doi: 10.1093/ijnp/pyx019.
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Potential Mechanisms of Hematological Adverse Drug Reactions in Patients Receiving Clozapine in Combination With Proton Pump Inhibitors.接受氯氮平联合质子泵抑制剂治疗的患者发生血液学药物不良反应的潜在机制。
J Psychiatr Pract. 2017 Mar;23(2):114-120. doi: 10.1097/PRA.0000000000000223.
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Interaction between clozapine and oxcarbazepine: a case report.氯氮平与奥卡西平的相互作用：一例报告。
Ther Adv Psychopharmacol. 2017 Feb;7(2):95-99. doi: 10.1177/2045125316681472. Epub 2016 Dec 15.