Division of Neonatology, Department of Pediatrics, University Hospital "A.Gemelli" Catholic University of the Sacred Heart, Rome, Italy.
Ital J Pediatr. 2018 Aug 22;44(1):99. doi: 10.1186/s13052-018-0542-5.
Continuous glucose monitoring using subcutaneous sensors is useful in the management of glucose control in neonatal intensive care. We evaluated feasibility and reliability of a continuous glucose monitoring system in a population of very low birth weight neonates needing parenteral nutrition. Moreover, we presented percentiles of glycemia of the studied population.
Very low birth weight neonates were enrolled within 24 h from birth. An ENLITE sensor connected to a continuous glucose monitoring system was inserted and maintained for at least 72 h. Data obtained with the continuous glucose monitoring system and with a glucometer were compared. Calibration was performed every 12 h.
Twenty-three patients (9 males) were included. Median gestational age was 28 weeks (range 23-30) and median birth weight was 860 g (range 500-1092). A total of 299 paired glucose values were obtained. Modified Clarke Error Grid criteria for clinical significance were met. 74 and 33 episodes of hypoglycemia and hyperglycemia were detected, respectively. 31,329 values of glycemia were analyzed and the percentiles calculated.
This continuous glucose monitoring system is safe and accurate. It allows increasing the detection of hypo- and hyper-glycaemia episodes and it could be routinely used in the management of glucose infusion in very low birth weight neonates under total parenteral nutrition.
皮下传感器的连续血糖监测在新生儿重症监护中控制血糖管理方面非常有用。我们评估了连续血糖监测系统在需要肠外营养的极低出生体重儿中的可行性和可靠性。此外，我们还提出了研究人群血糖百分位数。
极低出生体重儿在出生后 24 小时内入组。插入并维持 ENLITE 传感器至少 72 小时，与连续血糖监测系统相连。比较连续血糖监测系统和血糖仪获得的数据。每 12 小时进行一次校准。
23 例患者（9 例男性）入选。中位胎龄为 28 周（范围 23-30），中位出生体重为 860 克（范围 500-1092）。共获得 299 对葡萄糖值。满足临床意义的修正 Clarke 误差网格标准。分别检测到 74 次和 33 次低血糖和高血糖发作。分析了 31329 个血糖值并计算了百分位数。
这种连续血糖监测系统安全准确。它可以增加对低血糖和高血糖发作的检测，并且可以常规用于全肠外营养支持下极低出生体重儿葡萄糖输注的管理。
