Department of Neonatal Medicine, Princess Anne Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
Arch Dis Child Fetal Neonatal Ed. 2019 May;104(3):F235-F241. doi: 10.1136/archdischild-2018-315082. Epub 2018 Aug 22.
Previously published data have demonstrated that preterm infants experience a fall across marked centile lines for weight in early life with early poor head growth also reported. This study describes a single neonatal unit's experience of longitudinal change in weight, head circumference (HC) and length in a cohort of preterm infants born <32 weeks' gestation.
Data were collected from a single neonatal unit between July 2012 and June 2017. This period followed the introduction of improved nutritional guidelines. Patients were grouped according to their gestational age at birth. Growth lines were constructed for weight, HC and length in each gestational age group from the median measures and compared with reference centile lines.
Data were analysed from 396 patients consisting of 2808, 1991 and 2004 measures for weight, HC and length, respectively. Longitudinal growth plots did not show an initial absolute weight loss in any of the subgroups. Across all groups, the mean change in SD score between birth and 36 weeks was -0.27 (95% CI -0.39 to -0.15).
This description of longitudinal growth in a cohort of preterm infants demonstrates that early postnatal growth failure is not inevitable, with most infants growing along a trajectory close to their birth centile. There is no evidence of a 2 marked centile line weight decrease or weight loss. These data provide evidence to suggest that extrauterine weight gain tracking centile lines can be achieved.
先前发表的数据表明，早产儿在生命早期体重会明显下降，且头围增长也较差。本研究描述了一个新生儿病房中，<32 周早产儿的体重、头围（HC）和身长的纵向变化情况。
该研究数据来自于 2012 年 7 月至 2017 年 6 月间的一个新生儿病房。这一时期，新生儿营养指南得到了改进。根据出生时的胎龄，将患者分为不同的组别。从各胎龄组的中位数中构建体重、HC 和身长的生长曲线，并与参考百分位数曲线进行比较。
共分析了 396 名患者的数据，其中体重、HC 和身长的测量值分别为 2808、1991 和 2004 次。在所有亚组中，出生至 36 周时 SD 评分的平均变化为-0.27（95%CI-0.39 至-0.15）。
本研究描述了一组早产儿的纵向生长情况，表明早期的新生儿生长失败并非不可避免，大多数婴儿的生长轨迹接近其出生时的百分位数。没有证据表明体重会有两条明显的百分位线下降或体重下降。这些数据表明，宫外体重增长可以追踪到百分位线。
