The insulin cell: its cellular environment and how it processes (pro)insulin.

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作者信息

Orci L

出版信息

Diabetes Metab Rev. 1986;2(1-2):71-106. doi: 10.1002/dmr.5610020106.

DOI:10.1002/dmr.5610020106

PMID:3013544

Abstract

摘要

相似文献

The insulin cell: its cellular environment and how it processes (pro)insulin.

Diabetes Metab Rev. 1986;2(1-2):71-106. doi: 10.1002/dmr.5610020106.

Direct identification of prohormone conversion site in insulin-secreting cells.胰岛素分泌细胞中激素原转化位点的直接鉴定。

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The morphology of proinsulin processing.

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A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin.在莫能菌素存在的情况下，胰岛素分泌细胞中一个与高尔基体相关的网格蛋白包被小室会积累胰岛素原。

Cell. 1984 Nov;39(1):39-47. doi: 10.1016/0092-8674(84)90189-2.

Biosynthesis of insulin and glucagon.胰岛素与胰高血糖素的生物合成。

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(Pro)insulin associates with Golgi membranes of pancreatic B cells.（前）胰岛素与胰腺β细胞的高尔基体膜结合。

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Possibilities of false immunocytochemical results generated by the use of monoclonal antibodies: the example of the anti-proinsulin antibody.

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The trans-most cisternae of the Golgi complex: a compartment for sorting of secretory and plasma membrane proteins.高尔基体复合体最外侧的潴泡：一个用于分选分泌蛋白和质膜蛋白的区室。

Cell. 1987 Dec 24;51(6):1039-51. doi: 10.1016/0092-8674(87)90590-3.

Nonconverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane compartment.未转化的、氨基酸类似物修饰的胰岛素原停留在源自高尔基体的网格蛋白包被膜区室中。

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引用本文的文献

Human Islets Contain a Beta Cell Type That Expresses Proinsulin But Not the Enzyme That Converts the Precursor to Insulin.人类胰岛中存在一种β细胞类型，它表达胰岛素原，但不表达将前体转化为胰岛素的酶。

J Histochem Cytochem. 2020 Oct;68(10):691-702. doi: 10.1369/0022155420961361.

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.硫苷脂并非通过整合到晶格中，而是通过稳定胰岛素晶体表面来保存胰岛素晶体。

J Diabetes Res. 2016;2016:6179635. doi: 10.1155/2016/6179635. Epub 2016 Feb 14.

Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.无法转化的突变胰岛素原通过调节途径从原代大鼠β细胞中高效分泌。

Mol Biol Cell. 2003 Mar;14(3):1195-203. doi: 10.1091/mbc.e02-05-0299.

Electron-cytochemical localization of alkaline phosphatase to G cells of Necturus maculosus antrum.黄斑钝口螈胃窦G细胞碱性磷酸酶的电子细胞化学定位

Cell Tissue Res. 1989 Dec;258(3):555-61. doi: 10.1007/BF00218867.

The insulin secretory granule.胰岛素分泌颗粒

Diabetologia. 1989 May;32(5):271-81. doi: 10.1007/BF00265542.

Heterogeneous expression of glucokinase among pancreatic beta cells.胰腺β细胞中葡萄糖激酶的异质性表达。

Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2619-23. doi: 10.1073/pnas.89.7.2619.

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