Concentration of sulbactam and ampicillin in serum and the myometrium.

Sulbactam 1g and ampicillin 2g were administered intravenously to 12 patients, and concentrations of the drugs were determined in the serum and myometrium for up to 120 minutes after infusion. The ratio of sulbactam to ampicillin was about 1:2 in the serum and myometrium. Both drugs penetrated well into the myometrium, and median concentrations of sulbactam and ampicillin were 65% and 68%, respectively, of those in the serum. Sulbactam/ampicillin was effective for perioperative prophylaxis and should be effective as therapy for pelvic infections.