舒巴坦-氨苄西林和克拉维酸-阿莫西林在盆腔腹膜中的渗透情况。
Penetration of sulbactam-ampicillin and clavulanic acid-amoxicillin into the pelvic peritoneum.
作者信息
Houang E T, Colley N, Chapman M
出版信息
Antimicrob Agents Chemother. 1985 Jul;28(1):165-6. doi: 10.1128/AAC.28.1.165.
Abstract
Sixteen patients were given single intravenous injections of ampicillin (0.5 g) with sulbactam (0.5 g), and 15 patients were given amoxicillin (1 g) with clavulanic acid (0.2 g) before elective laparoscopy. At 2 h after dosing, the concentrations of the four compounds in serum and in the peritoneal fluid from the Pouch of Douglas and the ratio of each combination reached levels shown to be effective for antimicrobial activity in vitro.
摘要
16名患者在择期腹腔镜检查前接受了单次静脉注射氨苄西林（0.5g）与舒巴坦（0.5g），15名患者接受了阿莫西林（1g）与克拉维酸（0.2g）。给药后2小时，血清、Douglas陷凹处腹膜液中这四种化合物的浓度以及每种组合的比例达到了体外抗菌活性显示有效的水平。
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