Saddleson Megan L, Wileyto E Paul, Darwar Rahul, Ware Susan, Strasser Andrew A
Center for Interdisciplinary Research on Nicotine Addiction, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Tob Regul Sci. 2017 Jul;3(3):248-257. doi: 10.18001/TRS.3.3.1.
We examined the impact of cigarette filter collection on reports of cigarettes per day (CPD) versus self-reported CPD and to assess the utility of a pre-intervention baseline period in smoking studies.
Using baseline data from 522 non-treatment seeking smokers, we assessed differences in self-reported CPD via phone screen (CPD PS) and during baseline (CPD BL). We analyzed self-reported cigarette measures to predict carbon monoxide (CO), a measure of smoke exposure.
On average, CPD PS was 2.8 CPD more than CPD BL, and reporting multiples of 10 were more often found in CPD PS compared with CPD BL (54.7% vs17.2%, respectively). CPD BL was more strongly associated with CO than self-report CPD. Number of cigarettes smoked today, time since last cigarette, and nicotine dependence were significantly associated with CO.
CPD BL using filter collection is a more accurate measure of cigarette consumption than self-report, which may have implications for assessment of nicotine dependence. When feasible, studies should include a pre-intervention baseline period for comparison data with study outcomes. In addition to CPD BL, studies should assess time since last cigarette and the number of cigarettes smoked today when using CO as a biological measure of smoke exposure.
我们研究了收集香烟过滤嘴对每日吸烟量报告（CPD）与自我报告的CPD的影响，并评估吸烟研究中干预前基线期的效用。
利用522名未寻求治疗的吸烟者的基线数据，我们评估了通过电话筛查的自我报告CPD（CPD PS）与基线期（CPD BL）自我报告CPD之间的差异。我们分析了自我报告的香烟测量指标以预测一氧化碳（CO），这是一种衡量烟雾暴露的指标。
平均而言，CPD PS比CPD BL多2.8支/天，且与CPD BL相比，CPD PS中报告为10的倍数的情况更常见（分别为54.7%和17.2%）。CPD BL与CO的相关性比自我报告的CPD更强。今日吸烟支数、距上次吸烟的时间以及尼古丁依赖与CO显著相关。
使用过滤嘴收集的CPD BL比自我报告更准确地衡量香烟消费量，这可能对尼古丁依赖的评估有影响。在可行的情况下，研究应包括干预前基线期，以便与研究结果进行比较数据。除了CPD BL，研究在将CO用作烟雾暴露的生物学指标时，还应评估距上次吸烟的时间和今日吸烟支数。
