Cheung K, Teichert M, Moll H A, Stricker B H, Visser L E
Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Health and Youth Care Inspectorate, Utrecht, The Netherlands.
Int J Clin Pharm. 2018 Oct;40(5):1137-1143. doi: 10.1007/s11096-018-0717-6. Epub 2018 Aug 23.
Background Children are still prescribed age contraindicated drugs, but information about the number and type of these drugs dispensed for children in the Netherlands is limited. Objective To determine the incidence and prevalence of contraindicated drugs that were dispensed for the use by children. Setting The study was conducted in the Netherlands with routinely collected data from 95% of all community pharmacies. Method We performed a one-year nationwide observational study where all patients aged 17 years or younger who have received at least one prescription in 2016 were included. Contraindicated drugs were selected, according to the 5th level of ATC code, using different information sources. Main outcome measure The proportion of (newly) contraindicated drugs that were dispensed to children. Results In total, 3.9% of all children received at least one drug that was contraindicated for their age. The highest percentage of contraindicated drugs that was dispensed, was observed in patients aged 1-2 years and 13-17 years (7.0 and 5.7%, respectively) and the percentage of contraindicated drugs that were dispensed was higher in female than in male patients (4.3 and 3.6%, respectively; p value < 0.001). Conclusion The results of this study show that a substantial percentage of children received a drug that was conta-indicated for their age, and it happes more in female than in male patients. Furthermore, the information about this type of contraindications is limited and inconsistent.
背景 儿童仍会被开具年龄禁忌药物，但在荷兰，关于为儿童配药的此类药物数量和种类的信息有限。目的 确定为儿童配用的禁忌药物的发生率和流行率。地点 本研究在荷兰进行，数据来自95%的社区药房的常规收集。方法 我们进行了一项为期一年的全国性观察性研究，纳入了2016年至少接受过一张处方的所有17岁及以下患者。根据ATC代码的第5级，使用不同信息来源选择禁忌药物。主要结局指标 配发给儿童的（新）禁忌药物的比例。结果 总共3.9%的儿童至少接受了一种其年龄禁忌的药物。在1至2岁和13至17岁的患者中观察到配用禁忌药物的比例最高（分别为7.0%和5.7%），且女性患者配用禁忌药物的比例高于男性患者（分别为4.3%和3.6%；p值<0.001）。结论 本研究结果表明，相当比例的儿童接受了其年龄禁忌的药物，且女性患者比男性患者更易发生。此外，关于此类禁忌的信息有限且不一致。
