Beghi E, Di Mascio R
Ital J Neurol Sci. 1986 Apr;7(2):209-22. doi: 10.1007/BF02230884.
A detailed review of the adverse reactions of anticonvulsants is given, focusing on the definitions of drug toxicity, sources of information, patterns of drug utilization, pharmacokinetic variables and different mechanisms of action. The information available in the literature provides a wide spectrum of drug toxicity with no attempt at a practical definition of the reported events. This favors uncertainty among practising physicians, who are led to use the individual items with different attitudes. Suggestions are given for the evaluation, prevention and treatment of anticonvulsant drug toxicity.
本文详细综述了抗惊厥药物的不良反应，重点关注药物毒性的定义、信息来源、药物使用模式、药代动力学变量及不同作用机制。文献中可得的信息呈现出广泛的药物毒性，但未对所报告事件给出实际定义。这使得执业医师们感到困惑，他们在使用这些个体项目时态度各异。文中针对抗惊厥药物毒性的评估、预防及治疗给出了建议。
