Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
PLoS One. 2018 Aug 23;13(8):e0202651. doi: 10.1371/journal.pone.0202651. eCollection 2018.
High body mass index (BMI) is associated with development of hematological malignancies (HMs). However, although BMI is a well-established measurement of excess weight, it does not fully reflect body composition and can sometimes misclassify individuals. This study aimed at investigating what body composition measurements had highest association with development of HM. Body composition measurements on 27,557 individuals recorded by healthcare professionals as part of the Malmö Diet and Cancer study conducted in Sweden between 1991-1996 were matched with data from national registers on cancer incidence and causes of death. Cox regression models adjusted for age and sex were used to test the association between one standard deviation increments in body composition measurements and risk of HM. During a median follow-up of 20 years, 564 persons developed an HM. Several body composition measurements were associated with risk of developing an HM, but the strongest association was found for multiple myeloma (MM). Waist circumference (HR 1.31, p = 0.04) and waist-hip ratio (HR 1.61, p = 0.05) had higher risk estimates than BMI (HR 1.18, p = 0.07) for MM. In conclusion, our study shows that measurements of abdominal adiposity better predict the risk of developing HM, particularly MM, compared to BMI.
高身体质量指数（BMI）与血液系统恶性肿瘤（HMs）的发生有关。然而，尽管 BMI 是衡量超重的一个既定指标，但它并不能完全反映身体成分，有时会错误分类个体。本研究旨在探讨哪些身体成分测量指标与 HM 的发生相关性最高。在瑞典于 1991-1996 年间进行的马尔默饮食与癌症研究中，医疗保健专业人员记录了 27557 名个体的身体成分测量值，并与癌症发病率和死因的国家登记数据相匹配。使用 Cox 回归模型调整年龄和性别，测试身体成分测量值每增加一个标准差与 HM 风险之间的关联。在中位数为 20 年的随访期间，有 564 人发生了 HM。多项身体成分测量指标与 HM 发病风险相关，但与多发性骨髓瘤（MM）的相关性最强。腰围（HR 1.31，p = 0.04）和腰臀比（HR 1.61，p = 0.05）的风险估计值高于 BMI（HR 1.18，p = 0.07），与 MM 相关。总之，我们的研究表明，与 BMI 相比，腹部肥胖的测量值能更好地预测 HM，尤其是 MM 的发病风险。
