Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, United States of America.
Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.
PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0005919. doi: 10.1371/journal.pntd.0005919. eCollection 2018 Aug.
Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.
被忽视的热带病由后生动物寄生虫引起，是主要的公共卫生关注点，因此需要新的方法来控制和消除这些疾病。过去 25 年的研究揭示了半胱氨酸蛋白酶对（幼虫）蠕虫寄生虫通过宿主组织入侵和迁移的重要贡献，除了它们在胚胎发生、蜕皮、卵孵化和卵黄降解中的作用。它们在宿主中维持寄生虫生存的核心功能使它们成为新型药物和疫苗的主要干预靶点。本综述重点介绍了在人类宿主和胚胎发生的各种早期发育阶段中具有功能特征的那些蠕虫半胱氨酸蛋白酶。
