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药物相互作用在预测腹腔镜子宫肌瘤切除术后生育结局中的应用

[Application of DDI in prediction of fertility outcome after laparoscopic myomectomy].

作者信息

Liang X X, Zhang Z Y, Liu C D, Qu H

机构信息

Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2018 Aug 25;53(8):528-533. doi: 10.3760/cma.j.issn.0529-567x.2018.08.004.

DOI:10.3760/cma.j.issn.0529-567x.2018.08.004
PMID:30138962
Abstract

To analyze the application of difficulty degree index (DDI) in predicting patients's fertility outcome after laparoscopic myomectomy. A retrospective study was carried out on 118 patients with subserous myoma or intramural myoma undergoing laparoscopic myomectomy from January 2005 to December 2014. The rate of post-operative pregnancy, delivery outcome and disease recurrence were investigated. Logistic regression analysis was used to analyze the impact of DDI, the age of patients undergoing surgery, presence of infertility history etc, on the patients' reproductive outcome following the surgery. Follow-up for 1 to 10 years,118 cases were included in the study, the rate of post-operative pregnancy, live birth, vaginal delivery were 72.9% (86/118) , 52.5% (62/118) and 24.2% (15/62) respectively. No cases of uterine rupture and obstetric complications occurred. Univariate analysis showed that the independent variables of post-operative pregnancy rate were DDI, patient's age at the time of surgery, presence of infertility history and myoma recurrence (all 0.05) . In multivariate analysis, the factors of post-operative pregnancy rate were DDI (3.131, 95:1.012-8.894) , patient's age at the time of surgery (2.722, 95:1.048-7.067) and presence of infertility history (8.509, 95: 2.102-34.445) . DDI could be applied to predict post-operative pregnancy rate, with the increasing of DDI the post-operative pregnancy rate decreasing. The patients with high DDI scores, age>35 years old or presence of infertility history should get ready for pregnancy positively.

摘要

分析难度指数(DDI)在预测腹腔镜子宫肌瘤剔除术后患者生育结局中的应用。对2005年1月至2014年12月期间接受腹腔镜子宫肌瘤剔除术的118例浆膜下肌瘤或肌壁间肌瘤患者进行回顾性研究。调查术后妊娠率、分娩结局及疾病复发情况。采用逻辑回归分析DDI、手术患者年龄、不孕史等对术后生殖结局的影响。随访1至10年,118例纳入研究,术后妊娠率、活产率、阴道分娩率分别为72.9%(86/118)、52.5%(62/118)和24.2%(15/62)。未发生子宫破裂及产科并发症。单因素分析显示,术后妊娠率的独立变量为DDI、手术时患者年龄、不孕史及肌瘤复发(均P<0.05)。多因素分析中,术后妊娠率的因素为DDI(3.131,95%CI:1.012 - 8.894)、手术时患者年龄(2.722,95%CI:1.048 - 7.067)和不孕史(8.509,95%CI:2.102 - 34.445)。DDI可用于预测术后妊娠率,随着DDI升高,术后妊娠率降低。DDI评分高、年龄>35岁或有不孕史的患者应积极做好妊娠准备。

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