WNT16诱导人血管周围干细胞的增殖和成骨分化。
WNT16 induces proliferation and osteogenic differentiation of human perivascular stem cells.
作者信息
Meyers Carolyn A, Shen Jia, Lu Amy, James Aaron W
机构信息
Department of Pathology, Johns Hopkins University, 21205, USA.
UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and The Orthopaedic Hospital Research Center, 90095, USA.
出版信息
J Orthop. 2018 Aug 16;15(3):854-857. doi: 10.1016/j.jor.2018.08.021. eCollection 2018 Sep.
Abstract
Perivascular stem cells (PSC) are a progenitor population defined by their perivascular residence. Recent studies have examined the relative difference in Wnt ligands to induce PSC differentiation, including Wnt16. Here, we examine the role of Wnt16 in the proliferation and osteogenic differentiation of human PSC. Treatment of PSC with WNT16 significantly increased cell proliferation to a greater extent than did WNT3A. In addition, WNT16 showed a significant increase in osteogenic gene expression among PSC. These data demonstrate that WNT16 represents a combined mitogenic/pro-osteogenic stimulus that may play a functional role in human mesenchymal stem cell mediated bone repair.
摘要
血管周围干细胞（PSC）是一类因其血管周围定位而定义的祖细胞群体。最近的研究探讨了诱导PSC分化的Wnt配体之间的相对差异，包括Wnt16。在此，我们研究Wnt16在人PSC增殖和成骨分化中的作用。用WNT16处理PSC比用WNT3A处理能在更大程度上显著增加细胞增殖。此外，WNT16使PSC中的成骨基因表达显著增加。这些数据表明，WNT16代表一种促有丝分裂/促成骨刺激因子，可能在人间充质干细胞介导的骨修复中发挥功能性作用。
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