首发精神病的分层治疗方法：可行性随机对照“进阶”研究的理论依据、设计及基线数据
Method of levels therapy for first-episode psychosis: rationale, design and baseline data for the feasibility randomised controlled Next Level study.
作者信息
Griffiths Robert, Mansell Warren, Carey Timothy A, Edge Dawn, Emsley Richard, Tai Sara J
机构信息
NIHR Clinical Doctoral Research Fellow and Psychological Therapist, School of Psychological Sciences, The University of Manchester and Psychosis Research Unit, Greater Manchester Mental Health NHS Foundation Trust, UK.
Reader in Clinical Psychology, School of Psychological Sciences, The University of Manchester, UK.
出版信息
BJPsych Open. 2018 Aug 14;4(5):339-345. doi: 10.1192/bjo.2018.44. eCollection 2018 Sep.
BACKGROUND
Method of levels (MOL) is an innovative transdiagnostic cognitive therapy with potential advantages over existing psychological treatments for psychosis.
AIMS
The Next Level study is a feasibility randomised controlled trial (RCT) of MOL for people experiencing first-episode psychosis. It aims to determine the suitability of MOL for further testing in a definitive trial (trial registration ISRCTN13359355).
METHOD
The study uses a parallel group non-masked feasibilityRCT design with two conditions: (a) treatment as usual (TAU) and (b) TAU plus MOL. Participants ( = 36) were recruited from early intervention in psychosis services. Outcome measures are completed at baseline, 10 and 14 months. The primary outcomes are recruitment and retention.
RESULTS
Participants' demographic and clinical characteristics are presented along with baseline data.
CONCLUSIONS
Next Level has recruited to target, providing evidence that it is feasible to recruit to a RCT of MOL for first-episode psychosis.
DECLARATION OF INTEREST
None.
背景
分层法（MOL）是一种创新的跨诊断认知疗法，相较于现有的精神病心理治疗方法具有潜在优势。
目的
“更上一层楼”研究是一项针对首次发作精神病患者的分层法可行性随机对照试验（RCT）。其目的是确定分层法是否适合在确定性试验中进一步测试（试验注册号ISRCTN13359355）。
方法
该研究采用平行组非盲可行性随机对照试验设计，有两种情况：（a）常规治疗（TAU）和（b）常规治疗加分层法。参与者（n = 3）从精神病早期干预服务中招募。在基线、10个月和14个月时完成结局测量。主要结局是招募和保留情况。
结果
呈现了参与者的人口统计学和临床特征以及基线数据。
结论
“更上一层楼”研究已按目标招募，证明了为首次发作精神病患者招募到分层法随机对照试验是可行的。
利益声明
无。
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