Department of Community Medicine, Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Anesthesiology, Yasuj University of Medical Sciences, Yasuj, Iran.
Dermatol Ther. 2018 Sep;31(5):e12683. doi: 10.1111/dth.12683. Epub 2018 Aug 23.
Till now many treatments attempted to relieve uremic pruritus (UP) though none of them are definite treatment. In this study, we gathered all studies conducted on UP treatment since 2000-2016. We conducted a systematic review by searching the electronic databases (PubMed, Scopus, and Google scholar). Patients were with chronic kidney disease who complained of UP. Clinical trials and pilot studies in English and Persian which were done on patients with ESRD who complained of itching between 2000 till 2016 were gathered. A total of 166 articles were collected. After excluding articles 41 articles were remaining. Then UP treatments classified into two main groups: Medical (chemical and herbal medicine) and non-medical. Most studies measured UP by VAS scoring system in which patients described the severity. This scoring system is individual dependent. There are lots of studies on UP treatment though there are lots of controversies in studies. Finding a definite cure for this unpleasant symptom can improve patients' quality of life. Conducting further studies for each treatment on larger population is essential to improve quality of life among the end stage renal disease patients.
到目前为止，已经有许多治疗方法试图缓解尿毒症瘙痒（UP），但都没有明确的治疗方法。在这项研究中，我们收集了 2000 年至 2016 年期间所有关于 UP 治疗的研究。我们通过搜索电子数据库（PubMed、Scopus 和 Google Scholar）进行了系统评价。研究对象为患有慢性肾脏病并抱怨 UP 的患者。收集了 2000 年至 2016 年间用英语和波斯语对患有 ESRD 并抱怨瘙痒的患者进行的临床试验和试点研究。共收集了 166 篇文章。在排除了一些文章后，还有 41 篇文章。然后将 UP 的治疗方法分为两大类：医学（化学药物和草药）和非医学。大多数研究都是通过 VAS 评分系统来衡量 UP 的，患者可以通过该评分系统来描述其严重程度。然而，这种评分系统是因人而异的。尽管 UP 的治疗方法存在很多争议，但有很多研究都在关注 UP 的治疗。找到一种有效的方法来治疗这种令人不适的症状可以提高患者的生活质量。对每一种治疗方法进行进一步的研究，扩大研究人群，对于提高终末期肾病患者的生活质量是至关重要的。
