钯(II)催化的 2-吡啶酮 C5-芳基化反应：碘代芳烃的直接应用。
Direct Pd(II)-Catalyzed Site-Selective C5-Arylation of 2-Pyridone Using Aryl Iodides.
机构信息
Department of Chemistry , Indian Institute of Technology Kharagpur , Kharagpur 721302 , India.
出版信息
Org Lett. 2018 Sep 7;20(17):5167-5171. doi: 10.1021/acs.orglett.8b02112. Epub 2018 Aug 24.
PMID:30141333
Abstract
A straightforward Pd(II)-catalyzed general strategy was developed for the C5-selective arylation of the 2-pyridone core with easily available aryl iodides. The transformation was highly regioselective and accomplished with a wide scope and functional group tolerance. Silver nitrate played a crucial role in this direct site-selective arylation. The method was extended to synthesize biologically active molecules.
摘要
开发了一种直截了当的 Pd(II)催化策略，用于 2-吡啶酮核心与易得的芳基碘化物的 C5-选择性芳基化。该转化具有高度的区域选择性，并具有广泛的范围和官能团耐受性。在这种直接位点选择性芳基化中，硝酸银起着至关重要的作用。该方法已扩展用于合成生物活性分子。
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