Bohdanowicz Michal, Sajic Dusan
1 Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
2 Guelph Dermatology Research, Guelph, ON, Canada.
J Cutan Med Surg. 2019 Jan/Feb;23(1):102-104. doi: 10.1177/1203475418795823. Epub 2018 Aug 24.
Palmoplantar pustular psoriasis (PPPP) is a form of psoriasis that can be difficult to treat. We describe a case of PPPP in a patient who failed multiple therapies, including ustekinumab. The patient subsequently developed inflammatory bowel disease (IBD), and restarting ustekinumab, with inflammatory bowel disease loading doses and optimization, resulted in complete resolution of her PPPP. This success occurred after she developed tachyphylaxis against the usual dosing of ustekinumab, demonstrating a recapture of the treatment response.
掌跖脓疱型银屑病（PPPP）是一种难以治疗的银屑病类型。我们描述了一例PPPP患者，该患者对包括乌司奴单抗在内的多种治疗均无效。该患者随后患上了炎症性肠病（IBD），在给予炎症性肠病负荷剂量并优化治疗后重新使用乌司奴单抗，其PPPP完全缓解。这一成功发生在她对乌司奴单抗常规剂量产生快速耐受之后，表明重新获得了治疗反应。
