Al Ayed Mousab Yousef, Ababneh Mutasem, Alwin Robert Asirvatham, Alzaid Aus, Ahmed Rania Ahmed, Salman Ahmed, Musallam Maha Ali, Al Dawish Mohamed Abdulaziz
Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Int J Low Extrem Wounds. 2018 Sep;17(3):161-168. doi: 10.1177/1534734618793557. Epub 2018 Aug 24.
We sought to define the type and antibiotic sensitivity response of pathogens isolated from diabetic foot ulcers based on ulcer location and Wagner classification. This retrospective analysis was done among 126 patients between 40 and 70 years of age at the Prince Sultan Military Medical City, Riyadh, Saudi Arabia, using the swab culture method for microbiological assessment. Data on demographic variables, ulcer sites (location), and depth of ulcer (Wagner classification) were also collected. A total of 134 pathogens were isolated from 126 patients. The most common gram-negative pathogen identified was (15.6%), followed by spp (6.7%). The most common gram-positive pathogen was (35%), followed by (8.9%). The most widely accepted antibiotic to which the gram-negative bacteria were sensitive was gentamycin (20.1%), followed by ciprofloxacin (19%). The most routinely used antibiotic in the treatment of the gram-positive bacteria was erythromycin (16%), with trimethoprim-sulfamethoxazole (14.1%) being the next most effective. In conclusion, spp, , and were the most common causes of diabetic foot infections. However, the frequency of encountered pathogens and respective sensitivity to antibiotic therapy may be influenced by the location site and severity of the ulceration.
我们试图根据溃疡部位和瓦格纳分级来确定从糖尿病足溃疡中分离出的病原体类型及抗生素敏感性反应。本回顾性分析在沙特阿拉伯利雅得苏丹王子军事医疗城的126例40至70岁患者中进行，采用拭子培养法进行微生物评估。还收集了人口统计学变量、溃疡部位（位置）和溃疡深度（瓦格纳分级）的数据。共从126例患者中分离出134种病原体。鉴定出的最常见革兰氏阴性病原体是（15.6%），其次是spp（6.7%）。最常见的革兰氏阳性病原体是（35%），其次是（8.9%）。革兰氏阴性菌对其敏感的最广泛使用的抗生素是庆大霉素（20.1%），其次是环丙沙星（19%）。治疗革兰氏阳性菌最常用的抗生素是红霉素（16%），其次是甲氧苄啶 - 磺胺甲恶唑（14.1%），效果次之。总之，spp、和是糖尿病足感染最常见的病因。然而，所遇到的病原体频率及对抗生素治疗的各自敏感性可能受溃疡部位和严重程度的影响。
