a Department of Urology , Shanghai Children's Hospital, Shanghai Jiao Tong University , Shanghai , China.
J Biomater Sci Polym Ed. 2018 Oct;29(14):1657-1666. doi: 10.1080/09205063.2018.1498184. Epub 2018 Sep 25.
Ureteral stents are commonly used in urological practices but are frequently associated with patient discomfort, encrustation and stent-related infection. And a second procedure is needed to remove the stent. New biomaterials and designs have been attempted to solve these problems. The development of biodegradable ureteral stent shows promising prospects in future clinical applications. This article reviews the biomaterials and preparation methods commonly used in the present study of biodegradable ureteral stents. To date, none of the technological developments has lead to the 'ideal' biodegradable ureteral stent, but much progress has been made in the stent design by improving the physical characteristics and biocompatibility of the biomaterials. The controllability of degradation, the biggest problem faced currently, still needs to be further improved. In the future, the nanotechnology and chemical modification of biomaterials may be able to further optimize the properties of degradation.
输尿管支架在泌尿科中应用广泛，但常引起患者不适、支架结垢和支架相关感染，且需要二次手术取出支架。为解决这些问题，尝试了新型生物材料和设计。可生物降解输尿管支架的发展在未来的临床应用中显示出广阔的前景。本文综述了目前可生物降解输尿管支架研究中常用的生物材料和制备方法。迄今为止，虽然没有任何技术发展能够带来“理想”的可生物降解输尿管支架，但通过改善生物材料的物理特性和生物相容性，在支架设计方面已经取得了很大进展。目前面临的最大问题是降解的可控性，仍需要进一步提高。未来，生物材料的纳米技术和化学修饰可能进一步优化降解性能。
