Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.
Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.
J Magn Reson Imaging. 2019 Mar;49(3):668-677. doi: 10.1002/jmri.26272. Epub 2018 Aug 24.
The use of native T mapping for evaluation of hypertrophic cardiomyopathy (HCM) is being explored, and its combination with histogram analysis may benefit the accuracy of such assessments.
To investigate the relationship of segmental left ventricular wall thickness (LVWT), myocardial fibrosis, and strain parameters with segmental histogram parameters of native T mapping in HCM patients.
Retrospective.
Ninety-three HCM patients without previous cardiovascular diseases were included.
FIELD STRENGTH/SEQUENCE: 3.0T cardiac MR. Steady-state free precession cine imaging, modified Look-Locker inversion recovery, phase-sensitive inversion recovery.
Images were assessed by three experienced radiologists.
Mann-Whitney U-tests, area under the curve (AUC), Spearman's rank correlation, intraclass correlation coefficient, and Bland-Altman test were used for statistical analysis.
A higher LVWT value correlated with higher means, minimums, 10 /25 /50 /75 /90 percentiles, maximums, kurtosis, entropy, and lower SD and energy of T mapping (P < 0.05 for all), with the correlation being stronger for entropy and energy (Spearman's rho = 0.439 and -0.413, respectively) than other parameters. Late gadolinium enhancement positive (LGE+) segments exhibited higher mean, minimum, 10 /25 /50 /75 /90 percentiles, maximum, entropy, and lower energy of T times than late gadolinium enhancement negative (LGE-) segments (P < 0.001 for all). Impaired strain function parameters (peak thickening and thickening rate in radial, circumferential, and longitudinal directions) demonstrated a weak correlation with higher entropy (P < 0.001 for all) and lower energy (P < 0.001 for all).
Histogram parameters of native T mapping provide more information than mean T times alone. Among these parameters, entropy and energy may correlate better with LVWT, myocardial late gadolinium enhancement, and strain parameters than mean T times in HCM patients.
2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;49:668-677.
人们正在探索使用本地区分 T 映射来评估肥厚型心肌病（HCM），并且其与直方图分析相结合可能会提高此类评估的准确性。
研究 HCM 患者的节段性左心室壁厚度（LVWT）、心肌纤维化和应变参数与本地区分 T 映射的节段性直方图参数之间的关系。
回顾性研究。
93 名无先前心血管疾病的 HCM 患者。
磁场强度/序列：3.0T 心脏磁共振。稳态自由进动电影成像、改良 Look-Locker 反转恢复、相位敏感反转恢复。
由三位有经验的放射科医生进行图像评估。
使用 Mann-Whitney U 检验、曲线下面积（AUC）、Spearman 秩相关、组内相关系数和 Bland-Altman 检验进行统计分析。
较高的 LVWT 值与较高的平均值、最小值、10/25/50/75/90 百分位数、最大值、峰度、信息熵以及较低的标准偏差和能量相关（所有 P 值均 < 0.05），与其他参数相比，信息熵和能量的相关性更强（Spearman 相关系数分别为 0.439 和 -0.413）。钆延迟增强阳性（LGE+）节段的平均、最小值、10/25/50/75/90 百分位数、最大值、信息熵和能量均低于钆延迟增强阴性（LGE-）节段（所有 P 值均 < 0.001）。应变功能参数（径向、圆周和纵向的峰值增厚和增厚率）的峰值与较高的信息熵（所有 P 值均 < 0.001）和较低的能量（所有 P 值均 < 0.001）呈弱相关。
本地区分 T 映射的直方图参数比平均 T 值提供了更多的信息。在这些参数中，信息熵和能量可能比平均 T 值与 HCM 患者的 LVWT、心肌晚期钆增强和应变参数的相关性更好。
2 技术功效阶段：2 J. Magn. Reson. Imaging 2019;49:668-677.
