Department of Anesthesiology, Rush University Medical Center, Chicago, Illinois.
J Arthroplasty. 2018 Nov;33(11):3372-3378. doi: 10.1016/j.arth.2018.07.028. Epub 2018 Aug 4.
Total knee arthroplasty offers substantial improvements for patients as measured by functional status and quality of life; however, 8% to 34% of patients experience chronic postsurgical pain following surgery (CPSP). In addition to disruption in daily activities of life caused by the pain itself, CPSP has been associated with an overall reduction in quality of life following surgery. Risk factors for CPSP can be broadly defined as potentially modifiable or unlikely modifiable. Unlikely modifiable risks include gender, age, medical comorbidities, and socioeconomic status. Potentially modifiable risks include perioperative pain, physical function, psychological state, surgical factors, and possibly genomics. Understanding risks and the magnitude of their effect on outcomes such as CPSP is desirable because interventions designed to affect these factors may be able to dramatically improve outcomes.
全膝关节置换术在功能状态和生活质量方面为患者带来了显著的改善；然而，8%至 34%的患者在手术后会经历慢性术后疼痛（CPSP）。除了疼痛本身对日常生活活动的干扰外，CPSP 还与手术后整体生活质量的下降有关。CPSP 的风险因素可以广义地定义为可能可改变或不太可能可改变的因素。不太可能可改变的风险因素包括性别、年龄、合并症和社会经济地位。可能可改变的风险因素包括围手术期疼痛、身体功能、心理状态、手术因素，以及可能的基因组学。了解风险及其对 CPSP 等结果的影响程度是理想的，因为旨在影响这些因素的干预措施可能能够显著改善结果。
