Keenan Kate, Hipwell Alison E, Class Quetzal A, Mbayiwa Kimberley
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Dev Psychobiol. 2018 Nov;60(7):753-764. doi: 10.1002/dev.21773. Epub 2018 Aug 24.
The concept of the developmental origins of health and disease via prenatal programming has informed many etiologic models of health and development. Extensive experimental research in non-human animal models has revealed the impact of in utero exposure to stress on fetal development and neurodevelopment later in life. Stress exposure, however, is unlikely to occur de novo following conception, and pregnancy health is not independent of the health of the system prior to conception. For these reasons, the preconception period is emerging as an important new focus for research on adverse birth outcomes and offspring neurodevelopment. In this review, we summarize the existing evidence for the role of preconception stress exposure on pregnancy health and offspring neurodevelopment across species and discuss the implications of this model for addressing health disparities in obstetrics and offspring outcomes.
通过产前编程实现的健康与疾病发育起源的概念，为许多健康与发育的病因学模型提供了依据。在非人类动物模型中进行的大量实验研究揭示了子宫内暴露于应激对胎儿发育及日后神经发育的影响。然而，应激暴露不太可能在受孕后重新出现，而且孕期健康并非独立于受孕前身体系统的健康状况。基于这些原因，受孕前期正成为不良出生结局和后代神经发育研究的一个重要新焦点。在本综述中，我们总结了现有证据，证明受孕前应激暴露对跨物种孕期健康和后代神经发育的作用，并讨论了该模型对解决产科健康差异和后代结局的意义。
