葡萄膜黑色素瘤质子束照射后转移的预后因素。

Prognostic factors for metastasis following proton beam irradiation of uveal melanomas.

作者信息

Gragoudas E S, Seddon J M, Egan K M, Polivogianis L, Hsieh C C, Goitein M, Verhey L, Munzenrider J, Austin-Seymour M, Urie M

出版信息

Ophthalmology. 1986 May;93(5):675-80. doi: 10.1016/s0161-6420(86)33699-6.

DOI:10.1016/s0161-6420(86)33699-6

PMID:3014416

Abstract

Prognostic indicators for the development of metastasis following proton beam irradiation of uveal melanomas were evaluated for 510 patients treated from 1975 to 1984. Thirty-three patients developed metastasis (6.5%) from 3 to 51 months following treatment. The primary site of metastasis was the liver in 28 cases (85%). Both demographic and clinical factors were considered. The three leading predictors of survival without metastasis after proton beam irradiation in order of importance were: (1) largest diameter of the tumor; (2) location of the anterior margin of the tumor; and (3) age at treatment. Worse prognosis was associated with largest tumor diameter greater than 15.0 mm, tumor involvement of the ciliary body and age at treatment older than 59 years.

摘要

对1975年至1984年接受治疗的510例葡萄膜黑色素瘤患者进行质子束照射后转移发展的预后指标评估。33例患者在治疗后3至51个月发生转移（6.5%）。转移的主要部位是肝脏，共28例（85%）。研究考虑了人口统计学和临床因素。质子束照射后无转移生存的三个主要预测因素按重要性排序为：（1）肿瘤最大直径；（2）肿瘤前缘位置；（3）治疗时年龄。预后较差与肿瘤最大直径大于15.0 mm、睫状体受累以及治疗时年龄大于59岁有关。