Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil.
Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil.
Eur J Clin Invest. 2018 Nov;48(11):e13020. doi: 10.1111/eci.13020. Epub 2018 Sep 16.
Chronic kidney disease (CKD), which affects 10%-15% of the population, associates with a range of complications-such as cardiovascular disease, frailty, infections, muscle and bone disorders and premature ageing-that could be related to alterations of mitochondrial number, distribution, structure and function. As mitochondrial biogenesis, bioenergetics and the dynamic mitochondrial networks directly or indirectly regulate numerous intra- and extracellular functions, the mitochondria have emerged as an important target for interventions aiming at preventing or improving the treatment of complications in CKD. In this review, we discuss the possible role of bioactive food compounds and exercise in the modulation of the disturbed mitochondrial function in a uraemic milieu.
慢性肾脏病（CKD）影响了 10%-15%的人群，与一系列并发症相关，如心血管疾病、虚弱、感染、肌肉和骨骼疾病以及过早衰老，这些可能与线粒体数量、分布、结构和功能的改变有关。由于线粒体生物发生、生物能和动态线粒体网络直接或间接地调节众多细胞内和细胞外功能，线粒体已成为预防或改善 CKD 并发症治疗的干预措施的一个重要靶点。在这篇综述中，我们讨论了生物活性食物化合物和运动在调节尿毒症环境中失调的线粒体功能方面的可能作用。
