Kodama Satoru, Horikawa Chika, Fujihara Kazuya, Ishii Dai, Hatta Mariko, Takeda Yasunaga, Kitazawa Masaru, Matsubayashi Yasuhiro, Shimano Hitoshi, Kato Kiminori, Tanaka Shiro, Sone Hirohito
Department of Laboratory Medicine and Clinical Epidemiology for Prevention of Noncommunicable Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Department of Health and Nutrition, Faculty of Human Life Studies, University of Niigata Prefecture, Niigata, Japan.
Clin Nutr ESPEN. 2018 Oct;27:53-58. doi: 10.1016/j.clnesp.2018.07.001. Epub 2018 Jul 13.
BACKGROUND & AIMS: High intake of fruit and vegetables is recommended for cardiovascular health. However, there have been persistent beliefs that fruits having high concentrations of fructose elevate the level of triglycerides (TG) in blood unlike vegetables. This meta-analysis aims to clarify the relationship between fruit intake and TG or hypertriglyceridemia.
Electronic literature searches were conducted for observational studies that investigated the relationship between fruit intake and hypertriglyceridemia or intervention studies that investigated the effect of increasing fruit intake on TG. Each effect size was pooled with an inverse-variance method.
Five cross-sectional studies and only 2 intervention studies were eligible. The pooled odds ratio (OR) (95% confidence interval (CI)) of the 5 cross-sectional studies for the highest vs. the lowest fruit intake category was 0.79 (0.72-0.87). In these studies, the pooled OR for the highest vs. the lowest vegetable intake category was not significant (OR = 0.92; 95% CI, (0.82-1.03)). A linear dose-response association was observed between increases in fruit intake and ORs for hypertriglyceridemia; the OR (95% CI) for an incrementally increased intake of fruit by 1 serving/day was 0.91 (0.84-0.98).
This meta-analysis suggests that high intake of fruit but not vegetables is inversely associated with hypertriglyceridemia. More trials are needed to clarify whether increasing fruit intake would reduce the level of TG and/or incident hypertriglyceridemia.
为了心血管健康，建议大量摄入水果和蔬菜。然而，一直以来人们认为，与蔬菜不同，富含果糖的水果会提高血液中甘油三酯（TG）的水平。这项荟萃分析旨在阐明水果摄入量与TG或高甘油三酯血症之间的关系。
对调查水果摄入量与高甘油三酯血症之间关系的观察性研究或调查增加水果摄入量对TG影响的干预性研究进行电子文献检索。每种效应量采用逆方差法进行合并。
有5项横断面研究和仅2项干预性研究符合要求。5项横断面研究中，水果摄入量最高组与最低组的合并比值比（OR）（95%置信区间（CI））为0.79（0.72 - 0.87）。在这些研究中，蔬菜摄入量最高组与最低组的合并OR无统计学意义（OR = 0.92；95% CI，（0.82 - 1.03））。观察到水果摄入量增加与高甘油三酯血症的OR之间存在线性剂量反应关系；每天水果摄入量每增加1份，OR（95% CI）为0.91（0.84 - 0.98）。
这项荟萃分析表明，大量摄入水果而非蔬菜与高甘油三酯血症呈负相关。需要更多试验来阐明增加水果摄入量是否会降低TG水平和/或新发高甘油三酯血症的发生率。
