Baioumy Shereen A, Esawy Marwa M, Shabana Marwa A
Department of Microbiology and Immunology, Faculty of Human Medicine, Zagazig University, Egypt.
Department of Clinical Pathology, Faculty of Human Medicine, Zagazig University, Egypt.
Immunobiology. 2018 Dec;223(12):807-811. doi: 10.1016/j.imbio.2018.08.009. Epub 2018 Aug 20.
Chronic spontaneous urticaria (CSU) is a chronic type characterized by episodes of wheals with or without angioedema. Autoantibody against the alpha subunit of Fc epsilon receptor (FcεRIa) was detected in CSU patients' sera. The study aims to evaluate the clinical utility of skin tests in CSU patients. In addition, it assesses the presence of circulating FcεRIa in CSU patients and their correlation with other clinical and immunological variables. The study includes 40 healthy controls and 40 CSU patients who had urticaria symptoms for at least 8 weeks. All subjects underwent the following tests: autologous serum skin test (ASST), autologous plasma skin test (APST), immunoglobulin E (IgE), antinuclear antibodies (ANA), antithyroid antibodies (ATA). An in-house enzyme-linked immunosorbent assay was used for FcεRIa detection. The prevalence of ANA and ATA in CSU was 7.5% and 20% respectively. Total IgE was significantly higher in CSU than in controls (p < 0.0001). The study detected circulating antibody to FcεRIα in 2.5% of controls and 52.5% of CSU patients (p < 0.0001). The prevalence of antibody to FcεRIa was 27.3% and 83.3% of ASST negative and positive patients respectively (p = 0.0004). But the prevalence was 17.6% and 78.3% of APST negative and positive patients respectively (p = 0.0002). In conclusion, Circulating antibody to FcεRIa has a role in the pathogenic mechanisms of CSU.
慢性自发性荨麻疹（CSU）是一种慢性类型，其特征为出现风团，伴有或不伴有血管性水肿。在CSU患者血清中检测到针对Fcε受体α亚基（FcεRIa）的自身抗体。本研究旨在评估皮肤试验在CSU患者中的临床应用价值。此外，该研究还评估了CSU患者循环中FcεRIa的存在情况及其与其他临床和免疫学变量的相关性。该研究纳入了40名健康对照者和40名有至少8周荨麻疹症状的CSU患者。所有受试者均接受了以下检查：自体血清皮肤试验（ASST）、自体血浆皮肤试验（APST）、免疫球蛋白E（IgE）、抗核抗体（ANA）、抗甲状腺抗体（ATA）。采用内部酶联免疫吸附测定法检测FcεRIa。CSU患者中ANA和ATA的患病率分别为7.5%和20%。CSU患者的总IgE显著高于对照组（p < 0.0001）。该研究在2.5%的对照者和52.5%的CSU患者中检测到循环抗FcεRIα抗体（p < 0.0001）。ASST阴性和阳性患者中抗FcεRIa抗体的患病率分别为27.3%和83.3%（p = 0.0004）。但APST阴性和阳性患者中的患病率分别为17.6%和78.3%（p = 0.0002）。总之，循环抗FcεRIa抗体在CSU的发病机制中起作用。
