解析蛋白酶体构象动态和亚基间通讯的新视角。
Insights into Proteasome Conformation Dynamics and Intersubunit Communication.
机构信息
Department of Clinical Sciences and Translational Medicine, University of Roma Tor Vergata, Via Montpellier 1, I-00133 Roma, Italy.
Department of Clinical Sciences and Translational Medicine, University of Roma Tor Vergata, Via Montpellier 1, I-00133 Roma, Italy.
出版信息
Trends Biochem Sci. 2018 Nov;43(11):852-853. doi: 10.1016/j.tibs.2018.08.002. Epub 2018 Aug 22.
A recently published paper applies cryo-electron microscopy (EM) studies and biochemical/genetic approaches for the elucidation of the mechanisms linking nucleotide binding by ATPases, proteasome conformation dynamics, and gate opening of the 20S core particle. These insights potentially represent a milestone in our understanding of the structural dynamics of the 26S proteasome.
最近发表的一篇论文应用了低温电子显微镜（cryo-electron microscopy，简称 EM）研究和生化/遗传学方法，阐明了 ATP 酶结合核苷酸、蛋白酶体构象动力学和 20S 核心颗粒门控之间的连接机制。这些见解可能代表了我们对 26S 蛋白酶体结构动力学理解的一个里程碑。
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