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解析蛋白酶体构象动态和亚基间通讯的新视角。

Insights into Proteasome Conformation Dynamics and Intersubunit Communication.

机构信息

Department of Clinical Sciences and Translational Medicine, University of Roma Tor Vergata, Via Montpellier 1, I-00133 Roma, Italy.

Department of Clinical Sciences and Translational Medicine, University of Roma Tor Vergata, Via Montpellier 1, I-00133 Roma, Italy.

出版信息

Trends Biochem Sci. 2018 Nov;43(11):852-853. doi: 10.1016/j.tibs.2018.08.002. Epub 2018 Aug 22.

DOI:10.1016/j.tibs.2018.08.002
PMID:30145017
Abstract

A recently published paper applies cryo-electron microscopy (EM) studies and biochemical/genetic approaches for the elucidation of the mechanisms linking nucleotide binding by ATPases, proteasome conformation dynamics, and gate opening of the 20S core particle. These insights potentially represent a milestone in our understanding of the structural dynamics of the 26S proteasome.

摘要

最近发表的一篇论文应用了低温电子显微镜（cryo-electron microscopy，简称 EM）研究和生化/遗传学方法，阐明了 ATP 酶结合核苷酸、蛋白酶体构象动力学和 20S 核心颗粒门控之间的连接机制。这些见解可能代表了我们对 26S 蛋白酶体结构动力学理解的一个里程碑。

相似文献

1
Insights into Proteasome Conformation Dynamics and Intersubunit Communication.解析蛋白酶体构象动态和亚基间通讯的新视角。
Trends Biochem Sci. 2018 Nov;43(11):852-853. doi: 10.1016/j.tibs.2018.08.002. Epub 2018 Aug 22.
2
Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle.古菌 PAN 蛋白酶体的冷冻电镜结构揭示了环周 ATP 酶循环。
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):534-539. doi: 10.1073/pnas.1817752116. Epub 2018 Dec 17.
3
Structural insights into the functional cycle of the ATPase module of the 26S proteasome.26S蛋白酶体ATP酶模块功能循环的结构洞察
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1305-1310. doi: 10.1073/pnas.1621129114. Epub 2017 Jan 23.
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An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome.26S蛋白酶体的一种原子模型AAA-ATP酶/20S核心颗粒亚复合体。
Biochem Biophys Res Commun. 2009 Oct 16;388(2):228-33. doi: 10.1016/j.bbrc.2009.07.145. Epub 2009 Aug 3.
5
Molecular and cellular dynamics of the 26S proteasome.26S 蛋白酶体的分子和细胞动力学。
Biochim Biophys Acta Proteins Proteom. 2021 Mar;1869(3):140583. doi: 10.1016/j.bbapap.2020.140583. Epub 2020 Dec 13.
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High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx.蛋白酶体与ADP-AlFx复合物的高分辨率冷冻电镜结构
Cell Res. 2017 Mar;27(3):373-385. doi: 10.1038/cr.2017.12. Epub 2017 Jan 20.
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Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.26S 蛋白酶体构象景观的扩展覆盖范围揭示了肽酶门控的机制。
Cell Rep. 2018 Jul 31;24(5):1301-1315.e5. doi: 10.1016/j.celrep.2018.07.004.
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Insights into the molecular architecture of the 26S proteasome.对26S蛋白酶体分子结构的深入了解。
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11943-7. doi: 10.1073/pnas.0905081106. Epub 2009 Jul 6.
9
Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.核苷酸驱动的激活态人 26S 蛋白酶体 AAA-ATPase 解聚酶构象重排的结构机制。
Nat Commun. 2018 Apr 10;9(1):1360. doi: 10.1038/s41467-018-03785-w.
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ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.ATP与PAN或26S ATP酶结合会导致与20S蛋白酶体结合、门打开以及未折叠蛋白质的转位。
Mol Cell. 2005 Dec 9;20(5):687-98. doi: 10.1016/j.molcel.2005.10.019.

引用本文的文献

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Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution.卟啉衍生物通过其电荷分布来调节 20S 蛋白酶体的活性。
Biomolecules. 2022 May 24;12(6):741. doi: 10.3390/biom12060741.
2
Cooperative Binding of the Cationic Porphyrin Tris-T4 Enhances Catalytic Activity of 20S Proteasome Unveiling a Complex Distribution of Functional States.三-T4 阳离子卟啉的协同结合增强 20S 蛋白酶体的催化活性，揭示了功能状态的复杂分布。
Int J Mol Sci. 2020 Sep 29;21(19):7190. doi: 10.3390/ijms21197190.
3
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges.
蛋白酶体作为一个具有多种治疗潜力的可药物靶标：有切与非切的两面性。
Pharmacol Ther. 2020 Sep;213:107579. doi: 10.1016/j.pharmthera.2020.107579. Epub 2020 May 19.