Mathematical description of the interaction between prostaglandins and calcium.

The interpretation of the biological action of prostaglandins is very difficult because the shape of the dose-response curves in different assays is often unusual. Horrobin has attempted to explain these unusual curves by supposing special interactions between Ca and the prostaglandin receptors. This paper gives a mathematical description of his theoretical models. The results of computer simulation based on these models were in good agreement with the reported experimental observations.